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Compound Detail

CHEMBL218318

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COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(C#N)ccc3s2)CC1

Basic Information

ChEMBL ID CHEMBL218318
Phase Preclinical
Structure Type MOL
InChI Key PFYOIMYEJHJBDU-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

448.6
MW (Da)
4.11
ALogP
6
HBA
1
HBD
68.6
PSA (Ų)
0.53
QED
0
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C25H28N4O2S
MW 448.59
Aromatic Rings 3
Heavy Atoms 32
NP-Likeness -1.94

Activity Summary

Ki 3 meas. best 9.34

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(3) dopamine receptor
CHEMBL234
Ki 9.34 9.34 0.5 1
D(4) dopamine receptor
CHEMBL219
Ki 7.35 7.35 44.7 1
D(2) dopamine receptor
CHEMBL217
Ki 7.17 7.17 67.6 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
17266201 10.1021/jm0611152 Dopamine receptors; D2 & D3 1
17266201 10.1021/jm0611152 Dopamine receptors; D3 & D4 1
17266201 10.1021/jm0611152 D(2) dopamine receptor 1
17266201 10.1021/jm0611152 D(3) dopamine receptor 1
17266201 10.1021/jm0611152 D(4) dopamine receptor 1

Data from ChEMBL 36 via Core Engine