Assay Detail
Functional
CHEMBL1926262
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Cytotoxicity against human HL60 cells assessed as growth inhibition after 48 hrs by CCK-8 assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Carbamates of 4'-demethyl-4-deoxypodophyllotoxin: synthesis, cytotoxicity and cell cycle effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.19 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1923600 | — | — | 1 | 7.05 |
| CHEMBL1923603 | — | — | 1 | 6.67 |
| CHEMBL1923602 | — | — | 1 | 6.64 |
| CHEMBL1923595 | — | — | 1 | 6.40 |
| CHEMBL1923605 | — | — | 1 | 6.38 |
| CHEMBL63970 | DESOXYPODOPHYLLOTOXIN | — | 1 | 6.33 |
| CHEMBL1923597 | — | — | 1 | 6.17 |
| CHEMBL1923599 | — | — | 1 | 6.15 |
| CHEMBL1923601 | — | — | 1 | 6.03 |
| CHEMBL1923606 | — | — | 1 | 6.00 |
| CHEMBL1923596 | — | — | 1 | 5.99 |
| CHEMBL1923598 | — | — | 1 | 5.99 |
| CHEMBL1923604 | — | — | 1 | 5.99 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.54 |
| CHEMBL89905 | 4'-DEMETHYLDEOXYPODOPHYLLOTOXIN | — | 1 | 5.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1923600 | — | IC50 | = | 89.3 | nM | 7.05 |
| CHEMBL1923603 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL1923602 | — | IC50 | = | 231.0 | nM | 6.64 |
| CHEMBL1923595 | — | IC50 | = | 397.0 | nM | 6.40 |
| CHEMBL1923605 | — | IC50 | = | 416.0 | nM | 6.38 |
| CHEMBL63970 | DESOXYPODOPHYLLOTOXIN | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL1923597 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL1923599 | — | IC50 | = | 711.0 | nM | 6.15 |
| CHEMBL1923601 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL1923606 | — | IC50 | = | 988.0 | nM | 6.00 |
| CHEMBL1923596 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL1923598 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL1923604 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL89905 | 4'-DEMETHYLDEOXYPODOPHYLLOTOXIN | IC50 | = | 2960.0 | nM | 5.53 |