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Assay Detail

CHEMBL1929807

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human CEM cells by alamar blue assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CCRF-CEM
Confidence 1 — Organism
Curated By Autocuration

Target

CCRF-CEM (CHEMBL382)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis, biological evaluation and molecular modeling of 1,2,3-triazole analogs of combretastatin A-1.
Akselsen OW, Odlo K, Cheng JJ, Maccari G, Botta M, Hansen TV.
Bioorg Med Chem (2012) 20 : 234 -242
PubMed 22137934 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 4.58 4.58

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1927603 1 4.58
CHEMBL36255 COMBRETASTATIN A-1 1.0 1 -
CHEMBL67 COMBRETASTATIN A4 -1.0 1 -
CHEMBL1927601 1 -
CHEMBL1927602 1 -
CHEMBL1927604 1 -
CHEMBL1927605 1 -
CHEMBL1927606 1 -
CHEMBL1927607 1 -
CHEMBL1927608 1 -
CHEMBL1927609 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1927603 IC50 = 26000.0 nM 4.58
CHEMBL36255 COMBRETASTATIN A-1 IC50 > 100000.0 nM -
CHEMBL67 COMBRETASTATIN A4 IC50 > 100000.0 nM -
CHEMBL1927601 IC50 > 100000.0 nM -
CHEMBL1927602 IC50 > 100000.0 nM -
CHEMBL1927604 IC50 > 100000.0 nM -
CHEMBL1927605 IC50 > 100000.0 nM -
CHEMBL1927606 IC50 > 100000.0 nM -
CHEMBL1927607 IC50 > 100000.0 nM -
CHEMBL1927608 IC50 > 100000.0 nM -
CHEMBL1927609 IC50 > 100000.0 nM -