Assay Detail
Functional
CHEMBL1930117
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Depigmentation activity in mouse Melan-a cells assessed as inhibition of melanin formation after 4 days
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Melan-a |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Inhibitory activity of novel kojic acid derivative containing trolox moiety on melanogenesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.75 | 4.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1928639 | — | — | 1 | 4.75 |
| CHEMBL287556 | KOJIC ACID | — | 1 | - |
| CHEMBL153 | TROLOX | — | 1 | - |
| CHEMBL1928640 | — | — | 1 | - |
| CHEMBL1928641 | — | — | 1 | - |
| CHEMBL1928642 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1928639 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL287556 | KOJIC ACID | IC50 | = | 1600000.0 | nM | - |
| CHEMBL153 | TROLOX | IC50 | > | 300000.0 | nM | - |
| CHEMBL1928640 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL1928641 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL1928642 | — | IC50 | > | 200000.0 | nM | - |