Assay Detail
Functional
CHEMBL1930242
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against R5 tropic Human immunodeficiency virus 1 BAL infected in human PBMC cells assessed as reduction in viral replication by p24 detection based ELISA
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design and synthesis of pyridin-2-ylmethylaminopiperidin-1-ylbutyl amide CCR5 antagonists that are potent inhibitors of M-tropic (R5) HIV-1 replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 7.31 | 9.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1926899 | — | — | 1 | 9.02 |
| CHEMBL1926884 | — | — | 1 | 9.00 |
| CHEMBL1926886 | — | — | 1 | 8.70 |
| CHEMBL1926900 | — | — | 1 | 8.70 |
| CHEMBL1926893 | — | — | 1 | 8.66 |
| CHEMBL1926896 | — | — | 1 | 8.66 |
| CHEMBL1926904 | — | — | 1 | 8.48 |
| CHEMBL1927009 | — | — | 1 | 8.46 |
| CHEMBL1927010 | — | — | 1 | 8.44 |
| CHEMBL1927008 | — | — | 1 | 8.41 |
| CHEMBL1926885 | — | — | 1 | 7.85 |
| CHEMBL1926894 | — | — | 1 | 7.72 |
| CHEMBL1926891 | — | — | 1 | 7.65 |
| CHEMBL1926902 | — | — | 1 | 7.64 |
| CHEMBL1926898 | — | — | 1 | 7.59 |
| CHEMBL1926897 | — | — | 1 | 7.53 |
| CHEMBL1926901 | — | — | 1 | 7.49 |
| CHEMBL1926874 | — | — | 1 | 7.23 |
| CHEMBL1926883 | — | — | 1 | 7.05 |
| CHEMBL1926878 | — | — | 1 | 7.02 |
| CHEMBL1926872 | — | — | 1 | 6.96 |
| CHEMBL1926876 | — | — | 1 | 6.75 |
| CHEMBL1762313 | — | — | 1 | 6.66 |
| CHEMBL1926887 | — | — | 1 | 6.42 |
| CHEMBL1926875 | — | — | 1 | 6.42 |
| CHEMBL1926880 | — | — | 1 | 6.40 |
| CHEMBL1926890 | — | — | 1 | 5.98 |
| CHEMBL1926888 | — | — | 1 | 5.74 |
| CHEMBL1926873 | — | — | 1 | 5.66 |
| CHEMBL1926882 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1926899 | — | IC50 | = | 0.96 | nM | 9.02 |
| CHEMBL1926884 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1926886 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1926900 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1926893 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL1926896 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL1926904 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL1927009 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL1927010 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL1927008 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL1926885 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1926894 | — | IC50 | = | 18.9 | nM | 7.72 |
| CHEMBL1926891 | — | IC50 | = | 22.3 | nM | 7.65 |
| CHEMBL1926902 | — | IC50 | = | 23.1 | nM | 7.64 |
| CHEMBL1926898 | — | IC50 | = | 25.4 | nM | 7.59 |
| CHEMBL1926897 | — | IC50 | = | 29.6 | nM | 7.53 |
| CHEMBL1926901 | — | IC50 | = | 32.3 | nM | 7.49 |
| CHEMBL1926874 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL1926883 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL1926878 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL1926872 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1926876 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL1762313 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1926887 | — | IC50 | = | 376.0 | nM | 6.42 |
| CHEMBL1926875 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL1926880 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1926890 | — | IC50 | = | 1044.0 | nM | 5.98 |
| CHEMBL1926888 | — | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL1926873 | — | IC50 | = | 2170.0 | nM | 5.66 |
| CHEMBL1926882 | — | IC50 | = | 2880.0 | nM | 5.54 |
| CHEMBL1926877 | — | IC50 | = | 9633.0 | nM | 5.02 |
| CHEMBL1926889 | — | IC50 | = | 11479.0 | nM | 4.94 |
| CHEMBL1926881 | — | IC50 | > | 1300.0 | nM | - |
| CHEMBL1926879 | — | IC50 | > | 1250.0 | nM | - |
| CHEMBL1926903 | — | IC50 | > | 32149.0 | nM | - |