Assay Detail
Functional
CHEMBL1930561
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of C-terminal HA epitope tagged human TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein, Galpha16 by cAMP accumulation assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RD-HGA16 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Trace amine-associated receptor 1 is a stereoselective binding site for compounds in the amphetamine class.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 5.30 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL612 | DEXTROAMPHETAMINE | 4.0 | 1 | 6.22 |
| CHEMBL19393 | LEVAMFETAMINE | 4.0 | 1 | 5.89 |
| CHEMBL1201201 | METHAMPHETAMINE | 4.0 | 1 | 5.82 |
| CHEMBL1927026 | (S)-M-METHOXYAMPHETAMINE | — | 1 | 5.72 |
| CHEMBL1927024 | (S)-P-HYDROXYAMPHETAMINE | — | 1 | 5.53 |
| CHEMBL1230845 | — | — | 1 | 5.50 |
| CHEMBL1927030 | LEVMETAMFETAMINE | 2.0 | 1 | 5.48 |
| CHEMBL1927028 | — | — | 1 | 5.30 |
| CHEMBL1927027 | — | — | 1 | 5.19 |
| CHEMBL1788307 | — | — | 1 | 5.18 |
| CHEMBL1927025 | — | — | 1 | 4.93 |
| CHEMBL468880 | — | — | 1 | 4.81 |
| CHEMBL69700 | — | — | 1 | 4.50 |
| CHEMBL195390 | — | — | 1 | 4.13 |
| CHEMBL382757 | — | — | 1 | - |
| CHEMBL250881 | — | — | 1 | - |
| CHEMBL102594 | — | — | 1 | - |
| CHEMBL317634 | — | — | 1 | - |
| CHEMBL1927029 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL612 | DEXTROAMPHETAMINE | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL19393 | LEVAMFETAMINE | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1201201 | METHAMPHETAMINE | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1927026 | (S)-M-METHOXYAMPHETAMINE | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1927024 | (S)-P-HYDROXYAMPHETAMINE | EC50 | = | 2960.0 | nM | 5.53 |
| CHEMBL1230845 | — | EC50 | = | 3160.0 | nM | 5.50 |
| CHEMBL1927030 | LEVMETAMFETAMINE | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL1927028 | — | EC50 | = | 5020.0 | nM | 5.30 |
| CHEMBL1927027 | — | EC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL1788307 | — | EC50 | = | 6570.0 | nM | 5.18 |
| CHEMBL1927025 | — | EC50 | = | 11730.0 | nM | 4.93 |
| CHEMBL468880 | — | EC50 | = | 15340.0 | nM | 4.81 |
| CHEMBL69700 | — | EC50 | = | 31940.0 | nM | 4.50 |
| CHEMBL195390 | — | EC50 | = | 73700.0 | nM | 4.13 |
| CHEMBL382757 | — | EC50 | - | — | - | |
| CHEMBL250881 | — | EC50 | - | — | - | |
| CHEMBL102594 | — | EC50 | - | — | - | |
| CHEMBL317634 | — | EC50 | - | — | - | |
| CHEMBL1927029 | — | EC50 | - | — | - |