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Compound Detail

CHEMBL1927030

LEVMETAMFETAMINE
🧪 Phase II
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🧪 Phase II
CN[C@H](C)Cc1ccccc1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL1927030
Name LEVMETAMFETAMINE
Phase Phase II
Structure Type MOL
InChI Key MYWUZJCMWCOHBA-SECBINFHSA-N

Known Names

L-desoxyephedrine L-methamphetamine Levmetamfetamine Levmetamfetamine cii Levmetanfetamina Levomethamphetamine
5
Targets
13
Activities
2
Assay Types
0
PK Parameters
6
Publications
6
Known Names

Molecular Properties

149.2
MW (Da)
1.84
ALogP
1
HBA
1
HBD
12.0
PSA (Ų)
0.69
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Single Enantiomer

Flags

Natural Product
USAN Stem -fetamine
USAN Year 1998

Extended Properties

Molecular Formula C10H15N
MW 149.24
Aromatic Rings 1
Heavy Atoms 11
NP-Likeness -0.21

Activity Summary

EC50 11 meas. best 6.9
Ki 2 meas.

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Trace amine-associated receptor 1
CHEMBL4908
 EC50 6.9 6.095 125.5 4
Trace amine-associated receptor 1
CHEMBL3833
 EC50 6.63 6.2475 233.3 4
Trace amine-associated receptor 1
CHEMBL1926495
 EC50 5.6 5.6 2500.0 1
Trace amine-associated receptor 1
CHEMBL5857
 EC50 5.48 5.48 3300.0 1
Unchecked
CHEMBL612545
 EC50 5.01 5.01 9830.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Trace amine-associated receptor 1 EC50 = 125.5 nM 6.9 Activation of mouse TAAR1 transmembrane domain 6 Thr268(6.55)Met mutant expresse... 24354319
Trace amine-associated receptor 1 EC50 = 233.3 nM 6.63 Activation of rat wild type TAAR1 expressed in HEK293 cells assessed as stimulat... 24354319
Trace amine-associated receptor 1 EC50 = 330.4 nM 6.48 Activation of rat TAAR1 transmembrane domain 7 Asn287(7.39)Tyr mutant expressed ... 24354319
Trace amine-associated receptor 1 EC50 = 843.3 nM 6.07 Activation of mouse wild type TAAR1 expressed in HEK293 cells assessed as stimul... 24354319
Trace amine-associated receptor 1 EC50 = 1109.0 nM 5.96 Activation of rat TAAR1 transmembrane domain 6 Met268(6.55)Thr mutant expressed ... 24354319
Trace amine-associated receptor 1 EC50 = 1190.0 nM 5.92 Activation of rat TAAR1 expressed in HEK293 cells assessed as accumulation of [3... 22037049
Trace amine-associated receptor 1 EC50 = 1596.0 nM 5.8 Activation of mouse TAAR1 transmembrane domain 7 Tyr287(7.39)Asn mutant expresse... 24354319
Trace amine-associated receptor 1 EC50 = 2440.0 nM 5.61 Activation of mouse TAAR1 expressed in human HEK293 cells assessed as accumulati... 22037049
Trace amine-associated receptor 1 EC50 = 2500.0 nM 5.6 Activation of rhesus monkey TAAR1 expressed in RD-HGA16 cells co-expressing Gq p... 22037049
Trace amine-associated receptor 1 EC50 = 3300.0 nM 5.48 Activation of C-terminal HA epitope tagged human TAAR1 expressed in RD-HGA16 cel... 22037049
Unchecked EC50 = 9830.0 nM 5.01 Activation of chimeric rat-human expressed in human HEK293 cells assessed as acc... 22037049

Literature References

PubMed DOI Target Context # Activities
24354319 10.1021/jm401316v Trace amine-associated receptor 1 14
22037049 10.1016/j.bmc.2011.10.007 Trace amine-associated receptor 1 4
3397993 10.1021/jm00403a012 Amine oxidase [flavin-containing] B 2
24354319 10.1021/jm401316v Unchecked 2
28244748 10.1021/acs.jmedchem.7b00085 Rattus norvegicus 2
22037049 10.1016/j.bmc.2011.10.007 Unchecked 1

Data from ChEMBL 36 via Core Engine