Assay Detail
Functional
CHEMBL3110489
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of mouse TAAR1 transmembrane domain 7 Tyr287(7.39)Asn mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr by chemiluminescent assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploring the determinants of trace amine-associated receptor 1's functional selectivity for the stereoisomers of amphetamine and methamphetamine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.48 | 7.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL610 | PHENETHYLAMINE | — | 1 | 7.23 |
| CHEMBL19393 | LEVAMFETAMINE | 4.0 | 1 | 6.98 |
| CHEMBL612 | DEXTROAMPHETAMINE | 4.0 | 1 | 6.66 |
| CHEMBL1927030 | LEVMETAMFETAMINE | 2.0 | 1 | 5.80 |
| CHEMBL1201201 | METHAMPHETAMINE | 4.0 | 1 | 5.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL610 | PHENETHYLAMINE | EC50 | = | 58.6 | nM | 7.23 |
| CHEMBL19393 | LEVAMFETAMINE | EC50 | = | 104.5 | nM | 6.98 |
| CHEMBL612 | DEXTROAMPHETAMINE | EC50 | = | 218.8 | nM | 6.66 |
| CHEMBL1927030 | LEVMETAMFETAMINE | EC50 | = | 1596.0 | nM | 5.80 |
| CHEMBL1201201 | METHAMPHETAMINE | EC50 | = | 1822.0 | nM | 5.74 |