Assay Detail
Functional
CHEMBL1930655
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Activation of mouse TAAR1 expressed in human HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by liquid scintillation counting
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Trace amine-associated receptor 1 is a stereoselective binding site for compounds in the amphetamine class.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.91 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL612 | DEXTROAMPHETAMINE | 4.0 | 1 | 6.68 |
| CHEMBL1927024 | (S)-P-HYDROXYAMPHETAMINE | — | 1 | 6.55 |
| CHEMBL1201201 | METHAMPHETAMINE | 4.0 | 1 | 6.04 |
| CHEMBL1927030 | LEVMETAMFETAMINE | 2.0 | 1 | 5.61 |
| CHEMBL19393 | LEVAMFETAMINE | 4.0 | 1 | 5.30 |
| CHEMBL1230845 | — | — | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL612 | DEXTROAMPHETAMINE | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1927024 | (S)-P-HYDROXYAMPHETAMINE | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL1201201 | METHAMPHETAMINE | EC50 | = | 920.0 | nM | 6.04 |
| CHEMBL1927030 | LEVMETAMFETAMINE | EC50 | = | 2440.0 | nM | 5.61 |
| CHEMBL19393 | LEVAMFETAMINE | EC50 | = | 4960.0 | nM | 5.30 |
| CHEMBL1230845 | — | EC50 | = | 5650.0 | nM | 5.25 |