Assay Detail
Binding
CHEMBL1930657
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Activation of chimeric rat-human expressed in human HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by liquid scintillation counting
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Trace amine-associated receptor 1 is a stereoselective binding site for compounds in the amphetamine class.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.46 | 5.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL612 | DEXTROAMPHETAMINE | 4.0 | 1 | 5.95 |
| CHEMBL19393 | LEVAMFETAMINE | 4.0 | 1 | 5.51 |
| CHEMBL1201201 | METHAMPHETAMINE | 4.0 | 1 | 5.35 |
| CHEMBL1927030 | LEVMETAMFETAMINE | 2.0 | 1 | 5.01 |
| CHEMBL1927024 | (S)-P-HYDROXYAMPHETAMINE | — | 1 | - |
| CHEMBL1230845 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL612 | DEXTROAMPHETAMINE | EC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL19393 | LEVAMFETAMINE | EC50 | = | 3090.0 | nM | 5.51 |
| CHEMBL1201201 | METHAMPHETAMINE | EC50 | = | 4440.0 | nM | 5.35 |
| CHEMBL1927030 | LEVMETAMFETAMINE | EC50 | = | 9830.0 | nM | 5.01 |
| CHEMBL1927024 | (S)-P-HYDROXYAMPHETAMINE | EC50 | > | 5420.0 | nM | - |
| CHEMBL1230845 | — | EC50 | > | 8540.0 | nM | - |