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Assay Detail

CHEMBL1930591

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HCV genotype 1b infected in human HuH7 cells after 3 days by renilla luciferase reporter assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Hepacivirus hominis
Cell Type Huh-7
Confidence 1 — Organism
Curated By Autocuration

Target

Hepatitis C virus (CHEMBL379)
Type ORGANISM
Organism Hepacivirus hominis

Publication

The design, synthesis and biological evaluations of C-6 or C-7 substituted 2-hydroxyisoquinoline-1,3-diones as inhibitors of hepatitis C virus.
Chen YL, Tang J, Kesler MJ, Sham YY, Vince R, Geraghty RJ, Wang Z.
Bioorg Med Chem (2012) 20 : 467 -479
PubMed 22100256 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 23 5.40 6.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL73809 1 6.70
CHEMBL1928108 1 5.77
CHEMBL1928103 1 5.72
CHEMBL461036 1 5.41
CHEMBL1928104 1 5.37
CHEMBL1928114 1 5.02
CHEMBL1643 RIBAVIRIN 4.0 1 4.85
CHEMBL1928109 1 4.36
CHEMBL1928097 1 -
CHEMBL1928098 1 -
CHEMBL1928099 1 -
CHEMBL1928100 1 -
CHEMBL1928101 1 -
CHEMBL1928102 1 -
CHEMBL1928105 1 -
CHEMBL1928106 1 -
CHEMBL1928107 1 -
CHEMBL1928110 1 -
CHEMBL1928111 1 -
CHEMBL1928112 1 -
CHEMBL1928113 1 -
CHEMBL1928116 1 -
CHEMBL1928117 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL73809 EC50 = 200.0 nM 6.70
CHEMBL1928108 EC50 = 1700.0 nM 5.77
CHEMBL1928103 EC50 = 1900.0 nM 5.72
CHEMBL461036 EC50 = 3900.0 nM 5.41
CHEMBL1928104 EC50 = 4300.0 nM 5.37
CHEMBL1928114 EC50 = 9600.0 nM 5.02
CHEMBL1643 RIBAVIRIN EC50 = 14000.0 nM 4.85
CHEMBL1928109 EC50 = 44000.0 nM 4.36
CHEMBL1928097 EC50 - -
CHEMBL1928098 EC50 - -
CHEMBL1928099 EC50 - -
CHEMBL1928100 EC50 - -
CHEMBL1928101 EC50 - -
CHEMBL1928102 EC50 - -
CHEMBL1928105 EC50 - -
CHEMBL1928106 EC50 - -
CHEMBL1928107 EC50 - -
CHEMBL1928110 EC50 - -
CHEMBL1928111 EC50 - -
CHEMBL1928112 EC50 - -
CHEMBL1928113 EC50 - -
CHEMBL1928116 EC50 - -
CHEMBL1928117 EC50 - -