Assay Detail
Functional
CHEMBL1930596
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Anticancer activity against human A375 cells after 48 hrs by MTT assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and anticancer activity of 4β-alkylamidochalcone and 4β-cinnamido linked podophyllotoxins as apoptotic inducing agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 4.93 | 5.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.86 |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 5.58 |
| CHEMBL1927232 | — | — | 1 | 5.28 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.26 |
| CHEMBL1927243 | — | — | 1 | 5.24 |
| CHEMBL1927240 | — | — | 1 | 5.17 |
| CHEMBL1927233 | — | — | 1 | 5.11 |
| CHEMBL1927238 | — | — | 1 | 5.11 |
| CHEMBL1927231 | — | — | 1 | 5.03 |
| CHEMBL1927242 | — | — | 1 | 5.02 |
| CHEMBL1927225 | — | — | 1 | 5.01 |
| CHEMBL1927228 | — | — | 1 | 4.99 |
| CHEMBL1927239 | — | — | 1 | 4.99 |
| CHEMBL1927224 | — | — | 1 | 4.97 |
| CHEMBL1927227 | — | — | 1 | 4.94 |
| CHEMBL1927226 | — | — | 1 | 4.94 |
| CHEMBL1927236 | — | — | 1 | 4.94 |
| CHEMBL1927234 | — | — | 1 | 4.91 |
| CHEMBL1927223 | — | — | 1 | 4.89 |
| CHEMBL1927247 | — | — | 1 | 4.88 |
| CHEMBL1927241 | — | — | 1 | 4.87 |
| CHEMBL1927230 | — | — | 1 | 4.86 |
| CHEMBL1927248 | — | — | 1 | 4.85 |
| CHEMBL1927237 | — | — | 1 | 4.84 |
| CHEMBL1927246 | — | — | 1 | 4.84 |
| CHEMBL1927244 | — | — | 1 | 4.75 |
| CHEMBL1926691 | — | — | 1 | 4.75 |
| CHEMBL1927235 | — | — | 1 | 4.74 |
| CHEMBL1927221 | — | — | 1 | 4.74 |
| CHEMBL1927245 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL61 | PODOFILOX | IC50 | = | 2620.0 | nM | 5.58 |
| CHEMBL1927232 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 5510.0 | nM | 5.26 |
| CHEMBL1927243 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL1927240 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL1927233 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL1927238 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL1927231 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL1927242 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL1927225 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL1927228 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL1927239 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL1927224 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL1927236 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL1927227 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL1927226 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL1927234 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL1927223 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL1927247 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL1927241 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL1927230 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL1927248 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL1927237 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL1927246 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL1927244 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL1926691 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL1927235 | — | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL1927221 | — | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL1927245 | — | IC50 | = | 19100.0 | nM | 4.72 |
| CHEMBL1927222 | — | IC50 | = | 20100.0 | nM | 4.70 |
| CHEMBL1927229 | — | IC50 | = | 25800.0 | nM | 4.59 |
| CHEMBL27246 | CINNAMIC ACID | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL1927249 | — | IC50 | = | 91000.0 | nM | 4.04 |