Assay Detail
Functional
CHEMBL1930599
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Anticancer activity against human ACHN cells after 48 hrs by MTT assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | ACHN |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and anticancer activity of 4β-alkylamidochalcone and 4β-cinnamido linked podophyllotoxins as apoptotic inducing agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 4.96 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.10 |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 5.67 |
| CHEMBL1926691 | — | — | 1 | 5.66 |
| CHEMBL1927241 | — | — | 1 | 5.41 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.12 |
| CHEMBL1927243 | — | — | 1 | 5.12 |
| CHEMBL1927233 | — | — | 1 | 5.07 |
| CHEMBL1927235 | — | — | 1 | 5.04 |
| CHEMBL1927226 | — | — | 1 | 5.03 |
| CHEMBL1927240 | — | — | 1 | 5.02 |
| CHEMBL1927223 | — | — | 1 | 5.00 |
| CHEMBL1927229 | — | — | 1 | 4.99 |
| CHEMBL1927237 | — | — | 1 | 4.97 |
| CHEMBL1927239 | — | — | 1 | 4.97 |
| CHEMBL1927236 | — | — | 1 | 4.96 |
| CHEMBL1927224 | — | — | 1 | 4.92 |
| CHEMBL1927246 | — | — | 1 | 4.89 |
| CHEMBL1927232 | — | — | 1 | 4.88 |
| CHEMBL1927248 | — | — | 1 | 4.88 |
| CHEMBL1927228 | — | — | 1 | 4.87 |
| CHEMBL1927222 | — | — | 1 | 4.86 |
| CHEMBL1927230 | — | — | 1 | 4.86 |
| CHEMBL1927244 | — | — | 1 | 4.84 |
| CHEMBL1927238 | — | — | 1 | 4.80 |
| CHEMBL1927231 | — | — | 1 | 4.79 |
| CHEMBL1927221 | — | — | 1 | 4.78 |
| CHEMBL1927245 | — | — | 1 | 4.75 |
| CHEMBL1927247 | — | — | 1 | 4.75 |
| CHEMBL1927242 | — | — | 1 | 4.73 |
| CHEMBL1927225 | — | — | 1 | 4.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL61 | PODOFILOX | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL1926691 | — | IC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL1927241 | — | IC50 | = | 3910.0 | nM | 5.41 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 7610.0 | nM | 5.12 |
| CHEMBL1927243 | — | IC50 | = | 7540.0 | nM | 5.12 |
| CHEMBL1927233 | — | IC50 | = | 8510.0 | nM | 5.07 |
| CHEMBL1927235 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL1927226 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL1927240 | — | IC50 | = | 9460.0 | nM | 5.02 |
| CHEMBL1927223 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1927229 | — | IC50 | = | 10180.0 | nM | 4.99 |
| CHEMBL1927237 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL1927239 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL1927236 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL1927224 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL1927246 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL1927232 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL1927248 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL1927228 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL1927222 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL1927230 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL1927244 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL1927238 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL1927231 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL1927221 | — | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL1927245 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL1927247 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL1927242 | — | IC50 | = | 18600.0 | nM | 4.73 |
| CHEMBL1927225 | — | IC50 | = | 19500.0 | nM | 4.71 |
| CHEMBL1927227 | — | IC50 | = | 20800.0 | nM | 4.68 |
| CHEMBL1927234 | — | IC50 | = | 26700.0 | nM | 4.57 |
| CHEMBL27246 | CINNAMIC ACID | IC50 | = | 91000.0 | nM | 4.04 |
| CHEMBL1927249 | — | IC50 | = | 128000.0 | nM | - |