Assay Detail
Binding
CHEMBL1930622
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Inhibition of iNOS-mediated nitric oxide production in LPS-stimulated mouse BV2 cells measured after 24 hrs of post-stimulation by Griess reaction method
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | BV-2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Bis-chalcone analogues as potent NO production inhibitors and as cytotoxic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.03 | 6.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1928925 | — | — | 1 | 6.02 |
| CHEMBL1928924 | — | — | 1 | 5.74 |
| CHEMBL1928928 | — | — | 1 | 5.40 |
| CHEMBL1928921 | — | — | 1 | 5.26 |
| CHEMBL1928926 | — | — | 1 | 5.15 |
| CHEMBL1928923 | — | — | 1 | 5.09 |
| CHEMBL1929082 | — | — | 1 | 5.06 |
| CHEMBL7890 | L-NAME | 2.0 | 1 | 4.88 |
| CHEMBL1929083 | — | — | 1 | 4.75 |
| CHEMBL1928927 | — | — | 1 | 4.63 |
| CHEMBL1928922 | — | — | 1 | 4.59 |
| CHEMBL1926708 | — | — | 1 | 4.44 |
| CHEMBL1928929 | — | — | 1 | 4.36 |
| CHEMBL1929084 | — | — | 1 | - |
| CHEMBL1929085 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1928925 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL1928924 | — | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL1928928 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1928921 | — | IC50 | = | 5440.0 | nM | 5.26 |
| CHEMBL1928926 | — | IC50 | = | 7040.0 | nM | 5.15 |
| CHEMBL1928923 | — | IC50 | = | 8090.0 | nM | 5.09 |
| CHEMBL1929082 | — | IC50 | = | 8650.0 | nM | 5.06 |
| CHEMBL7890 | L-NAME | IC50 | = | 13350.0 | nM | 4.88 |
| CHEMBL1929083 | — | IC50 | = | 17740.0 | nM | 4.75 |
| CHEMBL1928927 | — | IC50 | = | 23290.0 | nM | 4.63 |
| CHEMBL1928922 | — | IC50 | = | 25690.0 | nM | 4.59 |
| CHEMBL1926708 | — | IC50 | = | 36310.0 | nM | 4.44 |
| CHEMBL1928929 | — | IC50 | = | 43270.0 | nM | 4.36 |
| CHEMBL1929084 | — | IC50 | - | — | - | |
| CHEMBL1929085 | — | IC50 | - | — | - |