Assay Detail
Functional
CHEMBL1930664
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against wild type HIV1 3B infected in human MT4 cells assessed as reduction in virus-induced cytopathogenicity after 5 days by MTT assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, synthesis and biological evaluation of cycloalkyl arylpyrimidines (CAPYs) as HIV-1 NNRTIs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 6.79 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 8.66 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.27 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.12 |
| CHEMBL593 | DELAVIRDINE | 4.0 | 1 | 7.80 |
| CHEMBL1927046 | — | — | 1 | 7.26 |
| CHEMBL1926689 | — | — | 1 | 7.02 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.68 |
| CHEMBL1927047 | — | — | 1 | 6.37 |
| CHEMBL1927037 | — | — | 1 | 6.02 |
| CHEMBL1927031 | — | — | 1 | 5.94 |
| CHEMBL1927038 | — | — | 1 | 5.80 |
| CHEMBL1927033 | — | — | 1 | 5.19 |
| CHEMBL1927032 | — | — | 1 | 5.17 |
| CHEMBL1927044 | — | — | 1 | - |
| CHEMBL1927045 | — | — | 1 | - |
| CHEMBL1927043 | — | — | 1 | - |
| CHEMBL1927042 | — | — | 1 | - |
| CHEMBL1927041 | — | — | 1 | - |
| CHEMBL1927040 | — | — | 1 | - |
| CHEMBL1927039 | — | — | 1 | - |
| CHEMBL1927036 | — | — | 1 | - |
| CHEMBL1927035 | — | — | 1 | - |
| CHEMBL1927034 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 5.4 | nM | 8.27 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 7.5 | nM | 8.12 |
| CHEMBL593 | DELAVIRDINE | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1927046 | — | EC50 | = | 55.0 | nM | 7.26 |
| CHEMBL1926689 | — | EC50 | = | 96.0 | nM | 7.02 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1927047 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL1927037 | — | EC50 | = | 960.0 | nM | 6.02 |
| CHEMBL1927031 | — | EC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL1927038 | — | EC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL1927033 | — | EC50 | = | 6490.0 | nM | 5.19 |
| CHEMBL1927032 | — | EC50 | = | 6710.0 | nM | 5.17 |
| CHEMBL1927044 | — | EC50 | > | 310.0 | nM | - |
| CHEMBL1927045 | — | EC50 | > | 88.0 | nM | - |
| CHEMBL1927043 | — | EC50 | > | 340.0 | nM | - |
| CHEMBL1927042 | — | EC50 | > | 360.0 | nM | - |
| CHEMBL1927041 | — | EC50 | > | 170.0 | nM | - |
| CHEMBL1927040 | — | EC50 | > | 1300.0 | nM | - |
| CHEMBL1927039 | — | EC50 | > | 1190.0 | nM | - |
| CHEMBL1927036 | — | EC50 | > | 1050.0 | nM | - |
| CHEMBL1927035 | — | EC50 | > | 320.0 | nM | - |
| CHEMBL1927034 | — | EC50 | > | 9990.0 | nM | - |