Assay Detail
Binding
CHEMBL1930719
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Escherichia coli HPPK using 6-hydroxymethyl-7,8-dihydropterin as substrate and [32P]-ATP
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (CHEMBL3217379) ↗| Type | SINGLE PROTEIN |
| Organism | Escherichia coli (strain K12) |
Publication
Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: New design with improved properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.93 | 6.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1928286 | — | — | 1 | 6.36 |
| CHEMBL1928285 | — | — | 1 | 5.50 |
| CHEMBL1928284 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1928286 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL1928285 | — | IC50 | = | 3160.0 | nM | 5.50 |
| CHEMBL1928284 | — | IC50 | > | 100000.0 | nM | - |