Assay Detail
Binding
CHEMBL1930739
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-emopamil from delta(8)-delta(7) sterol isomerase in guinea pig liver membranes
20
Total Activities
20
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (CHEMBL5525) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as σ₁ receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 8.21 | 9.70 |
| Ki(app) | 5 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1929281 | — | — | 1 | 9.70 |
| CHEMBL128358 | — | — | 1 | 9.17 |
| CHEMBL1929278 | — | — | 1 | 9.05 |
| CHEMBL1929277 | — | — | 1 | 8.96 |
| CHEMBL1929275 | — | — | 1 | 8.81 |
| CHEMBL1929280 | — | — | 1 | 8.68 |
| CHEMBL1929279 | — | — | 1 | 8.51 |
| CHEMBL1929287 | — | — | 1 | 8.42 |
| CHEMBL1929282 | — | — | 1 | 8.14 |
| CHEMBL305187 | IFENPRODIL | 2.0 | 1 | 7.82 |
| CHEMBL1929428 | — | — | 1 | 6.94 |
| CHEMBL1929430 | — | — | 1 | 6.67 |
| CHEMBL1929429 | — | — | 1 | 5.85 |
| CHEMBL1929284 | — | — | 1 | - |
| CHEMBL1929285 | — | — | 1 | - |
| CHEMBL1929286 | — | — | 1 | - |
| CHEMBL1929283 | — | — | 1 | - |
| CHEMBL1929288 | — | — | 1 | - |
| CHEMBL1929289 | — | — | 1 | - |
| CHEMBL1929276 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1929281 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL128358 | — | Ki | = | 0.67 | nM | 9.17 |
| CHEMBL1929278 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL1929277 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL1929275 | — | Ki | = | 1.54 | nM | 8.81 |
| CHEMBL1929280 | — | Ki | = | 2.11 | nM | 8.68 |
| CHEMBL1929279 | — | Ki | = | 3.07 | nM | 8.51 |
| CHEMBL1929287 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL1929282 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL305187 | IFENPRODIL | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL1929428 | — | Ki | = | 115.0 | nM | 6.94 |
| CHEMBL1929430 | — | Ki | = | 213.0 | nM | 6.67 |
| CHEMBL1929429 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL1929284 | — | Ki(app) | - | — | - | |
| CHEMBL1929285 | — | Ki(app) | - | — | - | |
| CHEMBL1929286 | — | Ki(app) | - | — | - | |
| CHEMBL1929283 | — | Ki(app) | - | — | - | |
| CHEMBL1929288 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1929289 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1929276 | — | Ki(app) | - | — | - |