Assay Detail
Binding
CHEMBL1931047
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Inhibition of electric eel AChE using acetylcholine chloride as substrate preincubated for 15 mins by Ellman's method
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Benzenediol-berberine hybrids: multifunctional agents for Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.27 | 7.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL602861 | — | — | 1 | 7.01 |
| CHEMBL1927128 | — | — | 1 | 6.91 |
| CHEMBL1927133 | — | — | 1 | 6.52 |
| CHEMBL12089 | BERBERINE CHLORIDE | 1.0 | 1 | 6.43 |
| CHEMBL1927129 | — | — | 1 | 6.38 |
| CHEMBL1927132 | — | — | 1 | 6.34 |
| CHEMBL1927127 | — | — | 1 | 6.31 |
| CHEMBL1927131 | — | — | 1 | 6.26 |
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 6.21 |
| CHEMBL1927130 | — | — | 1 | 6.20 |
| CHEMBL1927134 | — | — | 1 | 5.96 |
| CHEMBL1927135 | — | — | 1 | 5.85 |
| CHEMBL1927136 | — | — | 1 | 5.84 |
| CHEMBL1927137 | — | — | 1 | 5.49 |
| CHEMBL45 | MELATONIN | 4.0 | 1 | - |
| CHEMBL32749 | FERULATE | -1.0 | 1 | - |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL602861 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL1927128 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL1927133 | — | IC50 | = | 304.0 | nM | 6.52 |
| CHEMBL12089 | BERBERINE CHLORIDE | IC50 | = | 374.0 | nM | 6.43 |
| CHEMBL1927129 | — | IC50 | = | 422.0 | nM | 6.38 |
| CHEMBL1927132 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL1927127 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL1927131 | — | IC50 | = | 547.0 | nM | 6.26 |
| CHEMBL659 | GALANTAMINE | IC50 | = | 623.0 | nM | 6.21 |
| CHEMBL1927130 | — | IC50 | = | 628.0 | nM | 6.20 |
| CHEMBL1927134 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL1927135 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL1927136 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL1927137 | — | IC50 | = | 3210.0 | nM | 5.49 |
| CHEMBL45 | MELATONIN | IC50 | - | — | - | |
| CHEMBL32749 | FERULATE | IC50 | > | 100000.0 | nM | - |
| CHEMBL140 | CURCUMIN | IC50 | > | 100000.0 | nM | - |