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Assay Detail

CHEMBL1931050

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of equine serum BuChE using acetylcholine as substrate preincubated for 15 mins by Ellman's method
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Equus caballus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Butyrylcholinesterase (CHEMBL5077)
Type SINGLE PROTEIN
Organism Equus caballus

Publication

Benzenediol-berberine hybrids: multifunctional agents for Alzheimer's disease.
Jiang H, Wang X, Huang L, Luo Z, Su T, Ding K, Ding K, Li X.
Bioorg Med Chem (2011) 19 : 7228 -7235
PubMed 22041172 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.79 6.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1927130 1 6.05
CHEMBL1927133 1 6.02
CHEMBL1927127 1 5.89
CHEMBL1927134 1 5.84
CHEMBL1927132 1 5.78
CHEMBL1927128 1 5.76
CHEMBL1927135 1 5.75
CHEMBL1927131 1 5.72
CHEMBL1927129 1 5.65
CHEMBL1927137 1 5.65
CHEMBL1927136 1 5.60
CHEMBL659 GALANTAMINE 4.0 1 -
CHEMBL12089 BERBERINE CHLORIDE 1.0 1 -
CHEMBL140 CURCUMIN 3.0 1 -
CHEMBL32749 FERULATE -1.0 1 -
CHEMBL45 MELATONIN 4.0 1 -
CHEMBL602861 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1927130 IC50 = 898.0 nM 6.05
CHEMBL1927133 IC50 = 950.0 nM 6.02
CHEMBL1927127 IC50 = 1300.0 nM 5.89
CHEMBL1927134 IC50 = 1460.0 nM 5.84
CHEMBL1927132 IC50 = 1660.0 nM 5.78
CHEMBL1927128 IC50 = 1740.0 nM 5.76
CHEMBL1927135 IC50 = 1790.0 nM 5.75
CHEMBL1927131 IC50 = 1920.0 nM 5.72
CHEMBL1927129 IC50 = 2260.0 nM 5.65
CHEMBL1927137 IC50 = 2250.0 nM 5.65
CHEMBL1927136 IC50 = 2490.0 nM 5.60
CHEMBL659 GALANTAMINE IC50 - -
CHEMBL12089 BERBERINE CHLORIDE IC50 - -
CHEMBL140 CURCUMIN IC50 - -
CHEMBL32749 FERULATE IC50 - -
CHEMBL45 MELATONIN IC50 - -
CHEMBL602861 IC50 - -