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Assay Detail

CHEMBL1931135

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against human HEK293 cells after 2 days by alamar blue assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type HEK293
Confidence 1 — Organism
Curated By Autocuration

Target

HEK293 (CHEMBL614818)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and antitumor activity of conjugates of 5-Fluorouracil and emodin.
Zhao LM, Zhang LM, Liu JJ, Wan LJ, Chen YQ, Zhang SQ, Yan ZW, Jiang JH.
Eur J Med Chem (2012) 47 : 255 -260
PubMed 22093761 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 4.81 5.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL289277 EMODIN 1 5.89
CHEMBL1927334 1 5.34
CHEMBL1927338 1 4.53
CHEMBL1927335 1 4.52
CHEMBL185 FLUOROURACIL 4.0 1 4.37
CHEMBL1927336 1 4.18
CHEMBL1927327 1 -
CHEMBL1927328 1 -
CHEMBL1927329 1 -
CHEMBL1927330 1 -
CHEMBL1927331 1 -
CHEMBL1927332 1 -
CHEMBL1927333 1 -
CHEMBL1927337 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL289277 EMODIN IC50 = 1300.0 nM 5.89
CHEMBL1927334 IC50 = 4600.0 nM 5.34
CHEMBL1927338 IC50 = 29600.0 nM 4.53
CHEMBL1927335 IC50 = 30000.0 nM 4.52
CHEMBL185 FLUOROURACIL IC50 = 42900.0 nM 4.37
CHEMBL1927336 IC50 = 66600.0 nM 4.18
CHEMBL1927327 IC50 > 100000.0 nM -
CHEMBL1927328 IC50 - -
CHEMBL1927329 IC50 - -
CHEMBL1927330 IC50 - -
CHEMBL1927331 IC50 - -
CHEMBL1927332 IC50 - -
CHEMBL1927333 IC50 > 100000.0 nM -
CHEMBL1927337 IC50 > 100000.0 nM -