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Assay Detail

CHEMBL1931746

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against rat L6 cells after 72 hrs by resazurin-based spectrophotometric assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Rattus norvegicus
Cell Type L6
Confidence 1 — Organism
Curated By Autocuration

Target

L6 (CHEMBL614793)
Type CELL-LINE
Organism Rattus norvegicus

Publication

Bis(oxyphenylene)benzimidazoles: a novel class of anti-Plasmodium falciparum agents.
Mayence A, Vanden Eynde JJ, Kaiser M, Brun R, Yarlett N, Huang TL.
Bioorg Med Chem (2011) 19 : 7493 -7500
PubMed 22061825 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 27 4.99 7.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL61 PODOFILOX 4.0 1 7.92
CHEMBL428612 1 5.45
CHEMBL428119 1 5.45
CHEMBL1928414 1 5.30
CHEMBL1928422 1 5.23
CHEMBL403651 1 5.17
CHEMBL1928425 1 5.15
CHEMBL442471 1 5.11
CHEMBL1928417 1 5.10
CHEMBL258556 1 5.02
CHEMBL1928415 1 5.01
CHEMBL1928427 1 4.98
CHEMBL1928419 1 4.88
CHEMBL1928244 1 4.84
CHEMBL1928424 1 4.80
CHEMBL1928413 1 4.72
CHEMBL1928246 1 4.70
CHEMBL1928416 1 4.67
CHEMBL1928420 1 4.66
CHEMBL1928245 1 4.60
CHEMBL1928412 1 4.34
CHEMBL258555 1 4.32
CHEMBL1928421 1 4.14
CHEMBL1928426 1 4.10
CHEMBL1928411 1 -
CHEMBL1928418 1 -
CHEMBL1928423 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL61 PODOFILOX IC50 = 12.0 nM 7.92
CHEMBL428612 IC50 = 3560.0 nM 5.45
CHEMBL428119 IC50 = 3560.0 nM 5.45
CHEMBL1928414 IC50 = 5040.0 nM 5.30
CHEMBL1928422 IC50 = 5890.0 nM 5.23
CHEMBL403651 IC50 = 6820.0 nM 5.17
CHEMBL1928425 IC50 = 7020.0 nM 5.15
CHEMBL442471 IC50 = 7840.0 nM 5.11
CHEMBL1928417 IC50 = 7980.0 nM 5.10
CHEMBL258556 IC50 = 9610.0 nM 5.02
CHEMBL1928415 IC50 = 9820.0 nM 5.01
CHEMBL1928427 IC50 = 10390.0 nM 4.98
CHEMBL1928419 IC50 = 13080.0 nM 4.88
CHEMBL1928244 IC50 = 14400.0 nM 4.84
CHEMBL1928424 IC50 = 16010.0 nM 4.80
CHEMBL1928413 IC50 = 18940.0 nM 4.72
CHEMBL1928246 IC50 = 19800.0 nM 4.70
CHEMBL1928416 IC50 = 21230.0 nM 4.67
CHEMBL1928420 IC50 = 21920.0 nM 4.66
CHEMBL1928245 IC50 = 25380.0 nM 4.60
CHEMBL1928412 IC50 = 45980.0 nM 4.34
CHEMBL258555 IC50 = 48390.0 nM 4.32
CHEMBL1928421 IC50 = 72200.0 nM 4.14
CHEMBL1928426 IC50 = 79580.0 nM 4.10
CHEMBL1928411 IC50 = 101250.0 nM -
CHEMBL1928418 IC50 = 118340.0 nM -
CHEMBL1928423 IC50 > 172000.0 nM -