Assay Detail
Functional
CHEMBL1931884
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Antiviral activity against HCMV Towne infected in HFF cells incubated for 10 days by plaque reduction assay
19
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human betaherpesvirus 5 |
| Cell Type | HFF |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Tyrosine-based 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine and -adenine ((S)-HPMPC and (S)-HPMPA) prodrugs: synthesis, stability, antiviral activity, and in vivo transport studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.48 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1927639 | — | — | 2 | 6.92 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 6.85 |
| CHEMBL1927638 | — | — | 1 | 6.70 |
| CHEMBL1927637 | — | — | 1 | 6.64 |
| CHEMBL392630 | CYCLIC CIDOFOVIR | — | 1 | 6.60 |
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 6.55 |
| CHEMBL1927646 | — | — | 1 | 6.54 |
| CHEMBL1927645 | — | — | 1 | 6.52 |
| CHEMBL1927642 | — | — | 2 | 6.52 |
| CHEMBL286534 | — | — | 1 | 6.39 |
| CHEMBL1927641 | — | — | 1 | 6.35 |
| CHEMBL1926695 | — | — | 1 | 6.35 |
| CHEMBL1927643 | — | — | 1 | 5.89 |
| CHEMBL112159 | — | — | 1 | 5.89 |
| CHEMBL1927640 | — | — | 1 | - |
| CHEMBL1927644 | — | — | 1 | - |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1927639 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL182 | GANCICLOVIR | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1927638 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1927639 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1927637 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL392630 | CYCLIC CIDOFOVIR | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5314375 | CIDOFOVIR | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL1927646 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1927645 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1927642 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL286534 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL1927641 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL1926695 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL1927642 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL1927643 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL112159 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1927640 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL1927644 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL184 | ACYCLOVIR | IC50 | - | — | - |