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Assay Detail

CHEMBL1931885

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against human KB cells after 48 hrs by crystal violet staining based spectrophotometric analysis
20
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type KB
Confidence 1 — Organism
Curated By Autocuration

Target

KB (CHEMBL398)
Type CELL-LINE
Organism Homo sapiens

Publication

Tyrosine-based 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine and -adenine ((S)-HPMPC and (S)-HPMPA) prodrugs: synthesis, stability, antiviral activity, and in vivo transport studies.
Zakharova VM, Serpi M, Krylov IS, Peterson LW, Breitenbach JM, Borysko KZ, Drach JC, Collins M, Hilfinger JM, Kashemirov BA, McKenna CE.
J Med Chem (2011) 54 : 5680 -5693
PubMed 21812420 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 5.52 5.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL416771 1 5.52
CHEMBL1927637 1 -
CHEMBL1927638 1 -
CHEMBL1927639 2 -
CHEMBL1927640 1 -
CHEMBL1927641 1 -
CHEMBL1926695 1 -
CHEMBL1927642 2 -
CHEMBL1927643 1 -
CHEMBL1927644 1 -
CHEMBL1927646 1 -
CHEMBL286534 1 -
CHEMBL5314375 CIDOFOVIR 4.0 1 -
CHEMBL112159 1 -
CHEMBL392630 CYCLIC CIDOFOVIR 1 -
CHEMBL184 ACYCLOVIR 4.0 1 -
CHEMBL182 GANCICLOVIR 4.0 1 -
CHEMBL1927645 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL416771 IC50 = 3000.0 nM 5.52
CHEMBL1927637 IC50 > 100000.0 nM -
CHEMBL1927638 IC50 > 100000.0 nM -
CHEMBL1927639 IC50 > 100000.0 nM -
CHEMBL1927639 IC50 > 100000.0 nM -
CHEMBL1927640 IC50 > 100000.0 nM -
CHEMBL1927641 IC50 > 100000.0 nM -
CHEMBL1926695 IC50 > 100000.0 nM -
CHEMBL1927642 IC50 > 100000.0 nM -
CHEMBL1927643 IC50 > 100000.0 nM -
CHEMBL1927642 IC50 > 100000.0 nM -
CHEMBL1927645 IC50 > 100000.0 nM -
CHEMBL1927646 IC50 > 100000.0 nM -
CHEMBL286534 IC50 > 100000.0 nM -
CHEMBL5314375 CIDOFOVIR IC50 > 100000.0 nM -
CHEMBL112159 IC50 > 100000.0 nM -
CHEMBL392630 CYCLIC CIDOFOVIR IC50 > 100000.0 nM -
CHEMBL184 ACYCLOVIR IC50 - -
CHEMBL182 GANCICLOVIR IC50 - -
CHEMBL1927644 IC50 > 100000.0 nM -