Assay Detail
Functional
CHEMBL1932097
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against drug-resistance HIV1 RTMDR1 infected in human TZM-bl cells after 48 hrs by luciferase reporter gene assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | TZM-bl |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Anti-AIDS agents 85. Design, synthesis, and evaluation of 1R,2R-dicamphanoyl-3,3-dimethyldihydropyrano-[2,3-c]xanthen-7(1H)-one (DCX) derivatives as novel anti-HIV agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 6.74 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1928612 | — | — | 1 | 7.19 |
| CHEMBL1928440 | — | — | 1 | 7.13 |
| CHEMBL1928444 | — | — | 1 | 7.09 |
| CHEMBL435294 | — | — | 1 | 6.96 |
| CHEMBL1928611 | — | — | 1 | 6.80 |
| CHEMBL1928443 | — | — | 1 | 6.44 |
| CHEMBL1928445 | — | — | 1 | 6.43 |
| CHEMBL1928447 | — | — | 1 | 6.38 |
| CHEMBL1928615 | — | — | 1 | 6.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1928612 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL1928440 | — | EC50 | = | 74.0 | nM | 7.13 |
| CHEMBL1928444 | — | EC50 | = | 81.0 | nM | 7.09 |
| CHEMBL435294 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1928611 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1928443 | — | EC50 | = | 363.0 | nM | 6.44 |
| CHEMBL1928445 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL1928447 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL1928615 | — | EC50 | = | 546.0 | nM | 6.26 |