Assay Detail
Functional
CHEMBL1932300
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Agonist activity at human recombinant delta opioid receptor expressed in human HEK293 cells by [35S]GTPgammaS binding assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of quinolinomorphinan-4-ol derivatives as δ opioid receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 9.37 | 10.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL559518 | — | — | 1 | 10.74 |
| CHEMBL552308 | — | — | 1 | 10.33 |
| CHEMBL564538 | — | — | 1 | 10.22 |
| CHEMBL1929365 | — | — | 1 | 9.72 |
| CHEMBL327745 | — | — | 1 | 9.15 |
| CHEMBL13786 | — | — | 1 | 8.99 |
| CHEMBL1929364 | — | — | 1 | 8.75 |
| CHEMBL1929362 | — | — | 1 | 8.63 |
| CHEMBL13470 | SNC-80 | — | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL559518 | — | EC50 | = | 0.018 | nM | 10.74 |
| CHEMBL552308 | — | EC50 | = | 0.047 | nM | 10.33 |
| CHEMBL564538 | — | EC50 | = | 0.06 | nM | 10.22 |
| CHEMBL1929365 | — | EC50 | = | 0.19 | nM | 9.72 |
| CHEMBL327745 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL13786 | — | EC50 | = | 1.03 | nM | 8.99 |
| CHEMBL1929364 | — | EC50 | = | 1.77 | nM | 8.75 |
| CHEMBL1929362 | — | EC50 | = | 2.34 | nM | 8.63 |
| CHEMBL13470 | SNC-80 | EC50 | = | 15.7 | nM | 7.80 |