Compound Detail
CHEMBL1929364
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Basic Information
| ChEMBL ID | CHEMBL1929364 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KGFUJNANWKDXND-VNZMSGEBSA-N |
4
Targets
4
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
356.5
MW (Da)
3.85
ALogP
3
HBA
1
HBD
36.4
PSA (Ų)
0.66
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 9.0
EC50 1 meas. best 8.75
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Delta-type opioid receptor CHEMBL269 | Ki | 9.0 | 9.0 | 1.0 | 1 |
| Delta-type opioid receptor CHEMBL236 | EC50 | 8.75 | 8.75 | 1.8 | 1 |
| Mu-type opioid receptor CHEMBL270 | Ki | 7.29 | 7.29 | 51.8 | 1 |
| Kappa-type opioid receptor CHEMBL3952 | Ki | 6.58 | 6.58 | 263.4 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Delta-type opioid receptor | Ki | = | 1.0 | nM | 9.0 | Displacement of [3H]DADLE from delta opioid receptor in rat cerebrum membranes | 22197670 |
| Delta-type opioid receptor | EC50 | = | 1.77 | nM | 8.75 | Agonist activity at human recombinant delta opioid receptor expressed in human H... | 22197670 |
| Mu-type opioid receptor | Ki | = | 51.8 | nM | 7.29 | Displacement of [3H]DAMGO from mu opioid receptor in rat cerebrum membranes | 22197670 |
| Kappa-type opioid receptor | Ki | = | 263.4 | nM | 6.58 | Displacement of [3H]U-69,593 from kappa opioid receptor in guinea pig cerebrum m... | 22197670 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22197670 | 10.1016/j.bmc.2011.11.047 | Delta-type opioid receptor | 2 |
| 22197670 | 10.1016/j.bmc.2011.11.047 | Unchecked | 2 |
| 22197670 | 10.1016/j.bmc.2011.11.047 | Mu-type opioid receptor | 1 |
| 22197670 | 10.1016/j.bmc.2011.11.047 | Kappa-type opioid receptor | 1 |
Data from ChEMBL 36 via Core Engine