Assay Detail
Binding
CHEMBL1932339
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Inhibition of EGFR tyrosine kinase activity in EGF-stimulated human A431 cells after 60 mins by ELISA
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N⁴-Aryl-6-substitutedphenylmethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as receptor tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.82 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL29197 | — | — | 1 | 6.64 |
| CHEMBL1095465 | — | — | 1 | 6.62 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 5.92 |
| CHEMBL1095464 | — | — | 1 | 5.04 |
| CHEMBL1929555 | — | — | 1 | 4.90 |
| CHEMBL474538 | — | — | 1 | - |
| CHEMBL1929552 | — | — | 1 | - |
| CHEMBL1929553 | — | — | 1 | - |
| CHEMBL1929554 | — | — | 1 | - |
| CHEMBL1929556 | — | — | 1 | - |
| CHEMBL1929557 | — | — | 1 | - |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL29197 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1095465 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1095464 | — | IC50 | = | 9190.0 | nM | 5.04 |
| CHEMBL1929555 | — | IC50 | = | 12620.0 | nM | 4.90 |
| CHEMBL474538 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL1929552 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1929553 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL1929554 | — | IC50 | = | 112100.0 | nM | - |
| CHEMBL1929556 | — | IC50 | = | 112700.0 | nM | - |
| CHEMBL1929557 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL535 | SUNITINIB | IC50 | = | 172100.0 | nM | - |