Assay Detail
Functional
CHEMBL1935840
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Antiproliferative activity against human BT474 cells after 3 days by methylene blue staining
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BT-474 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel 5-alkynyl-4-anilinopyrimidines as potent, orally active dual inhibitors of EGFR and Her-2 tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.47 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1934626 | — | — | 1 | 7.30 |
| CHEMBL1934624 | — | — | 1 | 7.10 |
| CHEMBL1934625 | — | — | 1 | 7.10 |
| CHEMBL554 | LAPATINIB | 4.0 | 1 | 7.00 |
| CHEMBL1934623 | — | — | 1 | 6.77 |
| CHEMBL1934622 | — | — | 1 | 6.48 |
| CHEMBL1934628 | — | — | 1 | 6.39 |
| CHEMBL1934629 | — | — | 1 | 6.35 |
| CHEMBL1934621 | — | — | 1 | 6.28 |
| CHEMBL1934632 | — | — | 1 | 6.24 |
| CHEMBL1934631 | — | — | 1 | 6.19 |
| CHEMBL1934627 | — | — | 1 | 6.09 |
| CHEMBL1933083 | — | — | 1 | 6.08 |
| CHEMBL1934633 | — | — | 1 | 5.97 |
| CHEMBL1934630 | — | — | 1 | 5.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1934626 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1934624 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1934625 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL554 | LAPATINIB | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1934623 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1934622 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL1934628 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL1934629 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL1934621 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL1934632 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL1934631 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL1934627 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL1933083 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL1934633 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL1934630 | — | IC50 | = | 1830.0 | nM | 5.74 |