Assay Detail
Functional
CHEMBL1936043
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human recombinant CRF1 receptor expressed in CHO cells by cAMP assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Corticotropin-releasing factor receptor 1 (CHEMBL1800) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Lead diversification. Application to existing drug molecules: mifepristone 1 and antalarmin 8.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.74 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1934749 | — | — | 1 | 8.22 |
| CHEMBL1934751 | — | — | 1 | 7.96 |
| CHEMBL296641 | ANTALARMIN | — | 1 | 7.50 |
| CHEMBL1934750 | — | — | 1 | 7.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1934749 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL1934751 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL296641 | ANTALARMIN | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL1934750 | — | Ki | = | 52.0 | nM | 7.28 |