Assay Detail
Binding
CHEMBL1936149
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Displacement of [3H]-PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by liquid scintillation counting
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Prostaglandin E2 receptor EP3 subtype (CHEMBL4336) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery of a novel EP2/EP4 dual agonist with high subtype-selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 6.83 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL548 | DINOPROSTONE | 4.0 | 1 | 8.30 |
| CHEMBL1933724 | — | — | 1 | 7.82 |
| CHEMBL223151 | — | — | 1 | 7.58 |
| CHEMBL42027 | — | — | 1 | 7.41 |
| CHEMBL1933727 | — | — | 1 | 7.31 |
| CHEMBL222715 | — | — | 1 | 7.07 |
| CHEMBL1933728 | — | — | 1 | 7.07 |
| CHEMBL1933722 | — | — | 1 | 6.27 |
| CHEMBL1933725 | — | — | 1 | 6.11 |
| CHEMBL1933726 | — | — | 1 | 5.92 |
| CHEMBL1933719 | — | — | 1 | 5.80 |
| CHEMBL1933717 | — | — | 1 | 5.24 |
| CHEMBL1933718 | — | — | 1 | - |
| CHEMBL1933720 | — | — | 1 | - |
| CHEMBL1933721 | — | — | 1 | - |
| CHEMBL1933723 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL548 | DINOPROSTONE | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL1933724 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL223151 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL42027 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL1933727 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL222715 | — | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL1933728 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL1933722 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL1933725 | — | Ki | = | 770.0 | nM | 6.11 |
| CHEMBL1933726 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL1933719 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL1933717 | — | Ki | = | 5800.0 | nM | 5.24 |
| CHEMBL1933718 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1933720 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1933721 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1933723 | — | Ki | > | 10000.0 | nM | - |