Assay Detail
Binding
CHEMBL1936227
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Binding affinity to dopamine D1 receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Analogues of doxanthrine reveal differences between the dopamine D1 receptor binding properties of chromanoisoquinolines and hexahydrobenzo[a]phenanthridines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.94 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25856 | DIHYDREXIDINE | 2.0 | 1 | 8.21 |
| CHEMBL319707 | — | — | 1 | 8.06 |
| CHEMBL104571 | — | — | 1 | 7.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25856 | DIHYDREXIDINE | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL319707 | — | Ki | = | 8.7 | nM | 8.06 |
| CHEMBL104571 | — | Ki | = | 29.0 | nM | 7.54 |