Assay Detail
Binding
CHEMBL1936449
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Inhibition of ACAT1- mediated cholesteryl ester synthesis in macrophages
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Conformationally restricted analog and biotin-labeled probe based on beauveriolide III.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.72 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL449307 | — | — | 1 | 7.70 |
| CHEMBL505016 | — | — | 1 | 7.40 |
| CHEMBL1933478 | — | — | 1 | 6.96 |
| CHEMBL1933480 | — | — | 1 | 6.55 |
| CHEMBL1933479 | — | — | 1 | 6.51 |
| CHEMBL409855 | BEAUVERIOLIDE III | — | 1 | 6.39 |
| CHEMBL516093 | BEAUVERIOLIDE I | — | 1 | 6.11 |
| CHEMBL1933481 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL449307 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL505016 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1933478 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1933480 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL1933479 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL409855 | BEAUVERIOLIDE III | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL516093 | BEAUVERIOLIDE I | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL1933481 | — | IC50 | = | 800.0 | nM | 6.10 |