Assay Detail
Binding
CHEMBL1936638
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Displacement of [3H]PGD2 from human CRTh2 receptor expressed in 293 cells by scintillation counting in presence of 50 % human plasma
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimization of phenylacetic acid derivatives for CRTH2 and DP selective antagonism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.63 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1933918 | — | — | 1 | 8.22 |
| CHEMBL1933919 | — | — | 1 | 7.89 |
| CHEMBL1933917 | — | — | 1 | 7.82 |
| CHEMBL1933920 | — | — | 1 | 7.82 |
| CHEMBL570653 | — | — | 1 | 7.80 |
| CHEMBL589973 | — | — | 1 | 7.68 |
| CHEMBL1933915 | — | — | 1 | 7.19 |
| CHEMBL1933916 | — | — | 1 | 6.58 |
| CHEMBL1933762 | — | — | 1 | - |
| CHEMBL1933763 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1933918 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1933919 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1933917 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1933920 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL570653 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL589973 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1933915 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL1933916 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1933762 | — | IC50 | - | — | - | |
| CHEMBL1933763 | — | IC50 | - | — | - |