Assay Detail
Binding
CHEMBL1936643
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Inhibition of Erk phosphorylation in human HT-29 cells
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Fused thiophene derivatives as MEK inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.22 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1933936 | — | — | 1 | 8.30 |
| CHEMBL1933938 | — | — | 1 | 8.22 |
| CHEMBL1933937 | — | — | 1 | 8.05 |
| CHEMBL1933929 | — | — | 1 | 7.89 |
| CHEMBL1933934 | — | — | 1 | 7.75 |
| CHEMBL1933076 | — | — | 1 | 7.66 |
| CHEMBL1933926 | — | — | 1 | 7.37 |
| CHEMBL1933925 | — | — | 1 | 7.35 |
| CHEMBL1933935 | — | — | 1 | 7.29 |
| CHEMBL1933928 | — | — | 1 | 7.12 |
| CHEMBL1933923 | — | — | 1 | 7.04 |
| CHEMBL1933933 | — | — | 1 | 6.85 |
| CHEMBL1933924 | — | — | 1 | 6.65 |
| CHEMBL1933927 | — | — | 1 | 6.14 |
| CHEMBL1933931 | — | — | 1 | 6.01 |
| CHEMBL1933921 | — | — | 1 | 5.81 |
| CHEMBL1933930 | — | — | 1 | - |
| CHEMBL1933932 | — | — | 1 | - |
| CHEMBL1933922 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1933936 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1933938 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1933937 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1933929 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1933934 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1933076 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1933926 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL1933925 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL1933935 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL1933928 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL1933923 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL1933933 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1933924 | — | IC50 | = | 224.0 | nM | 6.65 |
| CHEMBL1933927 | — | IC50 | = | 717.0 | nM | 6.14 |
| CHEMBL1933931 | — | IC50 | = | 978.0 | nM | 6.01 |
| CHEMBL1933921 | — | IC50 | = | 1539.0 | nM | 5.81 |
| CHEMBL1933930 | — | IC50 | - | — | - | |
| CHEMBL1933932 | — | IC50 | - | — | - | |
| CHEMBL1933922 | — | IC50 | - | — | - |