Compound Detail
CHEMBL1933931
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Basic Information
| ChEMBL ID | CHEMBL1933931 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YGTFAXJBDZZDJI-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
474.3
MW (Da)
4.25
ALogP
4
HBA
3
HBD
78.4
PSA (Ų)
0.58
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Dual specificity mitogen-activated protein kinase kinase; MEK1/2 CHEMBL2111289 | IC50 | 7.85 | 7.85 | 14.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 6.01 | 6.01 | 978.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Dual specificity mitogen-activated protein kinase kinase; MEK1/2 | IC50 | = | 14.0 | nM | 7.85 | Inhibition of human MEK using fluorescein-labelled Erk-tide as substrate after 2... | 22119475 |
| Unchecked | IC50 | = | 978.0 | nM | 6.01 | Inhibition of Erk phosphorylation in human HT-29 cells | 22119475 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22119475 | 10.1016/j.bmcl.2011.10.105 | Unchecked | 1 |
| 22119475 | 10.1016/j.bmcl.2011.10.105 | HT-29 | 1 |
| 22119475 | 10.1016/j.bmcl.2011.10.105 | Dual specificity mitogen-activated protein kinase kinase; MEK1/2 | 1 |
Data from ChEMBL 36 via Core Engine