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Assay Detail

CHEMBL1936644

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Functional
Antiproliferative activity against human HT-29 cells
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HT-29
Confidence 1 — Organism
Curated By Autocuration

Target

HT-29 (CHEMBL384)
Type CELL-LINE
Organism Homo sapiens

Publication

Fused thiophene derivatives as MEK inhibitors.
Laing VE, Brookings DC, Carbery RJ, Simorte JG, Hutchings MC, Langham BJ, Lowe MA, Allen RA, Fetterman JR, Turner J, Meier C, Kennedy J, Merriman M.
Bioorg Med Chem Lett (2012) 22 : 472 -475
PubMed 22119475 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 6.23 7.27

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1933937 1 7.27
CHEMBL1933938 1 7.10
CHEMBL1933936 1 7.04
CHEMBL1933929 1 6.95
CHEMBL1933076 1 6.92
CHEMBL1933932 1 6.80
CHEMBL1933934 1 6.47
CHEMBL1933923 1 6.22
CHEMBL1933926 1 6.15
CHEMBL1933928 1 6.05
CHEMBL1933925 1 5.98
CHEMBL1933935 1 5.80
CHEMBL1933924 1 5.79
CHEMBL1933933 1 5.21
CHEMBL1933921 1 5.05
CHEMBL1933927 1 4.92
CHEMBL1933930 1 -
CHEMBL1933931 1 -
CHEMBL1933922 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1933937 IC50 = 54.0 nM 7.27
CHEMBL1933938 IC50 = 79.0 nM 7.10
CHEMBL1933936 IC50 = 91.0 nM 7.04
CHEMBL1933929 IC50 = 113.0 nM 6.95
CHEMBL1933076 IC50 = 120.0 nM 6.92
CHEMBL1933932 IC50 = 158.0 nM 6.80
CHEMBL1933934 IC50 = 340.0 nM 6.47
CHEMBL1933923 IC50 = 596.0 nM 6.22
CHEMBL1933926 IC50 = 710.0 nM 6.15
CHEMBL1933928 IC50 = 896.0 nM 6.05
CHEMBL1933925 IC50 = 1043.0 nM 5.98
CHEMBL1933935 IC50 = 1578.0 nM 5.80
CHEMBL1933924 IC50 = 1633.0 nM 5.79
CHEMBL1933933 IC50 = 6210.0 nM 5.21
CHEMBL1933921 IC50 = 8869.0 nM 5.05
CHEMBL1933927 IC50 = 12110.0 nM 4.92
CHEMBL1933930 IC50 - -
CHEMBL1933931 IC50 - -
CHEMBL1933922 IC50 - -