Assay Detail
Functional
CHEMBL1937295
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Antiplatelet activity in rabbit platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation treated for 5 mins before ADP challenge measured for 6 mins by microplate reader
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Plasma |
| Cell Type | Platelet |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of 2H-benzo[b][1,4]oxazin-3(4H)-one derivatives as platelet aggregation inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.95 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL833 | TICLOPIDINE | 4.0 | 1 | 5.50 |
| CHEMBL25 | ASPIRIN | 4.0 | 1 | 5.22 |
| CHEMBL1934986 | — | — | 1 | 4.99 |
| CHEMBL1934991 | — | — | 1 | 4.90 |
| CHEMBL1934990 | — | — | 1 | 4.86 |
| CHEMBL1934992 | — | — | 1 | 4.85 |
| CHEMBL1934987 | — | — | 1 | 4.82 |
| CHEMBL1934989 | — | — | 1 | 4.73 |
| CHEMBL1934988 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL833 | TICLOPIDINE | IC50 | = | 3180.0 | nM | 5.50 |
| CHEMBL25 | ASPIRIN | IC50 | = | 6070.0 | nM | 5.22 |
| CHEMBL1934986 | — | IC50 | = | 10140.0 | nM | 4.99 |
| CHEMBL1934991 | — | IC50 | = | 12680.0 | nM | 4.90 |
| CHEMBL1934990 | — | IC50 | = | 13920.0 | nM | 4.86 |
| CHEMBL1934992 | — | IC50 | = | 14240.0 | nM | 4.85 |
| CHEMBL1934987 | — | IC50 | = | 15170.0 | nM | 4.82 |
| CHEMBL1934989 | — | IC50 | = | 18780.0 | nM | 4.73 |
| CHEMBL1934988 | — | IC50 | = | 18830.0 | nM | 4.72 |