Assay Detail
Binding
CHEMBL1941191
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Inhibition of platelet COX1-mediated TXB2 production in LPS-induced human whole blood after 60 mins by radioimmunoassay
5
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel analgesic/anti-inflammatory agents: diarylpyrrole acetic esters endowed with nitric oxide releasing properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.94 | 5.02 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1939670 | — | — | 2 | 5.02 |
| CHEMBL1939680 | — | — | 2 | 4.91 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1939670 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL1939680 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL118 | CELECOXIB | IC50 | = | 12470.0 | nM | 4.90 |
| CHEMBL1939670 | — | Inhibition | - | % | - | |
| CHEMBL1939680 | — | Inhibition | - | % | - |