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Assay Detail

CHEMBL1941610

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Functional
Antiviral activity against HCV genotype 1b infected in Ava5 cells assessed as inhibition of viral replication after 3 days by blot hybridization analysis
ChEMBL ↗
72
Total Activities
36
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Hepacivirus hominis
Cell Type Ava5
Confidence 1 — Organism
Curated By Autocuration

Target

Hepatitis C virus (CHEMBL379) ↗
Type ORGANISM
Organism Hepacivirus hominis

Publication

Thiazolides as novel antiviral agents. 2. Inhibition of hepatitis C virus replication.
Stachulski AV, Pidathala C, Row EC, Sharma R, Berry NG, Lawrenson AS, Moores SL, Iqbal M, Bentley J, Allman SA, Edwards G, Helm A, Hellier J, Korba BE, Semple JE, Rossignol JF.
J Med Chem (2011) 54 : 8670 -8680
PubMed 22059983 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC90 36 - -
EC50 36 6.12 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL462415 — — 2 8.00
CHEMBL1940775 — — 2 7.22
CHEMBL1940773 — — 2 6.89
CHEMBL1545 TIZOXANIDE -1.0 2 6.82
CHEMBL1448 NICLOSAMIDE 4.0 2 6.80
CHEMBL1401 NITAZOXANIDE 4.0 2 6.68
CHEMBL1940641 — — 2 6.64
CHEMBL1241146 — — 2 6.46
CHEMBL1802239 — — 2 6.35
CHEMBL1801515 — — 2 6.30
CHEMBL1940766 — — 2 6.23
CHEMBL2079794 — — 2 5.82
CHEMBL1940642 — — 2 5.70
CHEMBL1940770 — — 2 5.70
CHEMBL1241361 — — 2 5.52
CHEMBL461542 — — 2 5.46
CHEMBL1940774 — — 2 5.42
CHEMBL1241360 — — 2 5.42
CHEMBL1940772 — — 2 5.42
CHEMBL1240568 — — 2 5.38
CHEMBL1241394 — — 2 5.31
CHEMBL1241273 — — 2 5.00
CHEMBL1940776 — — 2 -
CHEMBL1241442 — — 2 -
CHEMBL578881 — — 2 -
CHEMBL1940769 — — 2 -
CHEMBL1801514 — — 2 -
CHEMBL1242480 — — 2 -
CHEMBL1801516 — — 2 -
CHEMBL1940768 — — 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL462415 — EC50 = 10.0 nM 8.00
CHEMBL1940775 — EC50 = 60.0 nM 7.22
CHEMBL1940773 — EC50 = 130.0 nM 6.89
CHEMBL1545 TIZOXANIDE EC50 = 150.0 nM 6.82
CHEMBL1448 NICLOSAMIDE EC50 = 160.0 nM 6.80
CHEMBL1401 NITAZOXANIDE EC50 = 210.0 nM 6.68
CHEMBL1940641 — EC50 = 230.0 nM 6.64
CHEMBL1241146 — EC50 = 350.0 nM 6.46
CHEMBL1802239 — EC50 = 450.0 nM 6.35
CHEMBL1801515 — EC50 = 500.0 nM 6.30
CHEMBL1940766 — EC50 = 590.0 nM 6.23
CHEMBL2079794 — EC50 = 1500.0 nM 5.82
CHEMBL1940642 — EC50 = 2000.0 nM 5.70
CHEMBL1940770 — EC50 = 2000.0 nM 5.70
CHEMBL1241361 — EC50 = 3000.0 nM 5.52
CHEMBL461542 — EC50 = 3500.0 nM 5.46
CHEMBL1241360 — EC50 = 3800.0 nM 5.42
CHEMBL1940774 — EC50 = 3800.0 nM 5.42
CHEMBL1940772 — EC50 = 3800.0 nM 5.42
CHEMBL1240568 — EC50 = 4200.0 nM 5.38
CHEMBL1241394 — EC50 = 4900.0 nM 5.31
CHEMBL1241273 — EC50 = 10000.0 nM 5.00
CHEMBL1940767 — EC90 > 8.2 uM -
CHEMBL1241442 — EC90 > 10.0 uM -
CHEMBL1801514 — EC50 > 10000.0 nM -
CHEMBL1240568 — EC90 = 14.0 uM -
CHEMBL1801514 — EC90 > 10.0 uM -
CHEMBL2079794 — EC90 = 5.2 uM -
CHEMBL1801515 — EC90 = 1.7 uM -
CHEMBL1940770 — EC90 = 4.6 uM -
CHEMBL578881 — EC90 >= 10.0 uM -
CHEMBL1241273 — EC90 = 10.0 uM -
CHEMBL1241444 — EC90 > 10.0 uM -
CHEMBL1241274 — EC90 > 10.0 uM -
CHEMBL1241302 — EC90 > 10.0 uM -
CHEMBL1940766 — EC90 = 8.9 uM -
CHEMBL1242480 — EC90 > 7.0 uM -
CHEMBL1801516 — EC90 > 10.0 uM -
CHEMBL1940769 — EC90 > 10.0 uM -
CHEMBL1940772 — EC90 = 11.0 uM -
CHEMBL1940773 — EC90 = 0.83 uM -
CHEMBL1940774 — EC90 = 21.0 uM -
CHEMBL1802239 — EC90 = 3.4 uM -
CHEMBL462415 — EC90 = 0.03 uM -
CHEMBL461542 — EC90 = 8.1 uM -
CHEMBL1940775 — EC90 = 0.46 uM -
CHEMBL1940776 — EC90 > 10.0 uM -
CHEMBL1448 NICLOSAMIDE EC90 = 0.7 uM -
CHEMBL1241444 — EC50 > 10000.0 nM -
CHEMBL1940769 — EC50 > 10000.0 nM -