Assay Detail
Functional
CHEMBL1941613
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Antiviral activity against HCV genotype 1a infected in Huh7.5 cells assessed as inhibition of viral replication after 3 days by blot hybridization analysis
32
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Thiazolides as novel antiviral agents. 2. Inhibition of hepatitis C virus replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 5.94 | 6.60 |
| EC90 | 16 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1545 | TIZOXANIDE | -1.0 | 2 | 6.60 |
| CHEMBL1401 | NITAZOXANIDE | 4.0 | 2 | 6.48 |
| CHEMBL1241146 | — | — | 2 | 6.41 |
| CHEMBL1940641 | — | — | 2 | 6.40 |
| CHEMBL1940766 | — | — | 2 | 6.00 |
| CHEMBL1241394 | — | — | 2 | 5.55 |
| CHEMBL1241361 | — | — | 2 | 5.52 |
| CHEMBL1241360 | — | — | 2 | 5.48 |
| CHEMBL1241274 | — | — | 2 | 5.00 |
| CHEMBL1801516 | — | — | 2 | - |
| CHEMBL1242480 | — | — | 2 | - |
| CHEMBL578881 | — | — | 2 | - |
| CHEMBL1940767 | — | — | 2 | - |
| CHEMBL1241444 | — | — | 2 | - |
| CHEMBL1801507 | — | — | 2 | - |
| CHEMBL1241359 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1545 | TIZOXANIDE | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1401 | NITAZOXANIDE | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL1241146 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL1940641 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1940766 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1241394 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL1241361 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1241360 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL1241274 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1241360 | — | EC90 | = | 10.0 | uM | - |
| CHEMBL1242480 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1241146 | — | EC90 | = | 2.3 | uM | - |
| CHEMBL1940641 | — | EC90 | = | 1.9 | uM | - |
| CHEMBL1545 | TIZOXANIDE | EC90 | = | 1.0 | uM | - |
| CHEMBL1801516 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1241359 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1801507 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1241444 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1940767 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL578881 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1801516 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL1242480 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL578881 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL1940767 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL1241444 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL1241274 | — | EC90 | = | 10.0 | uM | - |
| CHEMBL1940766 | — | EC90 | = | 3.8 | uM | - |
| CHEMBL1801507 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL1241361 | — | EC90 | = | 8.6 | uM | - |
| CHEMBL1241359 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL1401 | NITAZOXANIDE | EC90 | = | 1.1 | uM | - |
| CHEMBL1241394 | — | EC90 | = | 9.4 | uM | - |