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Assay Detail

CHEMBL1941920

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of COX-1-mediated PGE2 production in arachidonic acid-stimulated mouse J774 cells incubated for 15 mins prior to arachidonic acid-challenge by radioimmunoassay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mus musculus
Cell Type J774
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Prostaglandin G/H synthase 1 (CHEMBL2649)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Novel analgesic/anti-inflammatory agents: diarylpyrrole acetic esters endowed with nitric oxide releasing properties.
Biava M, Porretta GC, Poce G, Battilocchio C, Alfonso S, Rovini M, Valenti S, Giorgi G, Calderone V, Martelli A, Testai L, Sautebin L, Rossi A, Papa G, Ghelardini C, Di Cesare Mannelli L, Giordani A, Anzellotti P, Bruno A, Patrignani P, Anzini M.
J Med Chem (2011) 54 : 7759 -7771
PubMed 21992176 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 5.52 5.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1939671 1 5.96
CHEMBL1939514 1 5.50
CHEMBL118 CELECOXIB 4.0 1 5.42
CHEMBL1939676 1 5.19
CHEMBL1939670 1 -
CHEMBL1939668 1 -
CHEMBL1939672 1 -
CHEMBL1939673 1 -
CHEMBL1939674 1 -
CHEMBL1939675 1 -
CHEMBL192678 1 -
CHEMBL1939677 1 -
CHEMBL1939669 1 -
CHEMBL1939680 1 -
CHEMBL1939511 1 -
CHEMBL1939512 1 -
CHEMBL1939513 1 -
CHEMBL1939667 1 -
CHEMBL1939515 1 -
CHEMBL1939516 1 -
CHEMBL1939517 1 -
CHEMBL1939518 1 -
CHEMBL1939678 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1939671 IC50 = 1100.0 nM 5.96
CHEMBL1939514 IC50 = 3180.0 nM 5.50
CHEMBL118 CELECOXIB IC50 = 3840.0 nM 5.42
CHEMBL1939676 IC50 = 6400.0 nM 5.19
CHEMBL1939670 IC50 > 10000.0 nM -
CHEMBL1939668 IC50 > 10000.0 nM -
CHEMBL1939672 IC50 > 10000.0 nM -
CHEMBL1939673 IC50 > 10000.0 nM -
CHEMBL1939674 IC50 > 10000.0 nM -
CHEMBL1939675 IC50 > 10000.0 nM -
CHEMBL192678 IC50 > 10000.0 nM -
CHEMBL1939677 IC50 > 10000.0 nM -
CHEMBL1939669 IC50 > 10000.0 nM -
CHEMBL1939680 IC50 > 10000.0 nM -
CHEMBL1939511 IC50 > 10000.0 nM -
CHEMBL1939512 IC50 > 10000.0 nM -
CHEMBL1939513 IC50 > 10000.0 nM -
CHEMBL1939667 IC50 > 10000.0 nM -
CHEMBL1939515 IC50 > 10000.0 nM -
CHEMBL1939516 IC50 > 10000.0 nM -
CHEMBL1939517 IC50 > 10000.0 nM -
CHEMBL1939518 IC50 > 10000.0 nM -
CHEMBL1939678 IC50 > 10000.0 nM -