Assay Detail
Binding
CHEMBL1941925
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Inhibition of COX-2-mediated PGE2 production in LPS-stimulated mouse J774 cells after 24 hrs by radioimmunoassay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | J774 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel analgesic/anti-inflammatory agents: diarylpyrrole acetic esters endowed with nitric oxide releasing properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.21 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1939677 | — | — | 1 | 8.62 |
| CHEMBL1939671 | — | — | 1 | 8.14 |
| CHEMBL1939667 | — | — | 1 | 7.89 |
| CHEMBL1939674 | — | — | 1 | 7.77 |
| CHEMBL1939670 | — | — | 1 | 7.72 |
| CHEMBL1939511 | — | — | 1 | 7.64 |
| CHEMBL1939675 | — | — | 1 | 7.57 |
| CHEMBL1939672 | — | — | 1 | 7.54 |
| CHEMBL1939673 | — | — | 1 | 7.43 |
| CHEMBL1939512 | — | — | 1 | 7.41 |
| CHEMBL1939669 | — | — | 1 | 7.38 |
| CHEMBL1939668 | — | — | 1 | 7.37 |
| CHEMBL1939513 | — | — | 1 | 7.25 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 7.21 |
| CHEMBL1939680 | — | — | 1 | 7.07 |
| CHEMBL1939514 | — | — | 1 | 7.07 |
| CHEMBL1939678 | — | — | 1 | 7.02 |
| CHEMBL1939676 | — | — | 1 | 6.77 |
| CHEMBL1939515 | — | — | 1 | 6.58 |
| CHEMBL1939518 | — | — | 1 | 6.30 |
| CHEMBL1939517 | — | — | 1 | 6.16 |
| CHEMBL192678 | — | — | 1 | 6.00 |
| CHEMBL1939516 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1939677 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL1939671 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL1939667 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1939674 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1939670 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1939511 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1939675 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1939672 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL1939673 | — | IC50 | = | 37.2 | nM | 7.43 |
| CHEMBL1939512 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL1939669 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL1939668 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL1939513 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL118 | CELECOXIB | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL1939680 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL1939514 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL1939678 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL1939676 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1939515 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1939518 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1939517 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL192678 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1939516 | — | IC50 | = | 1100.0 | nM | 5.96 |