Assay Detail
Binding
CHEMBL1942065
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of His-tagged AKT1 using 5FAM-GRPRTSSFAEGCONH2 as substrate by fluorescence based assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
RAC-alpha serine/threonine-protein kinase (CHEMBL4282) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of novel, potent, and selective inhibitors of 3-phosphoinositide-dependent kinase (PDK1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.76 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1940249 | — | — | 1 | 8.00 |
| CHEMBL1940250 | — | — | 1 | 7.00 |
| CHEMBL1940251 | — | — | 1 | 6.77 |
| CHEMBL1940246 | — | — | 1 | 6.68 |
| CHEMBL1940248 | — | — | 1 | 6.64 |
| CHEMBL1938415 | — | — | 1 | 6.58 |
| CHEMBL1940252 | — | — | 1 | 6.44 |
| CHEMBL1940253 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1940249 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL1940250 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL1940251 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL1940246 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL1940248 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL1938415 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL1940252 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL1940253 | — | Ki | = | 1100.0 | nM | 5.96 |