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Assay Detail

CHEMBL1942527

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of LSD1
14
Total Activities
14
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Lysine-specific histone demethylase 1A (CHEMBL6136)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Lysine demethylases inhibitors.
Suzuki T, Miyata N.
J Med Chem (2011) 54 : 8236 -8250
PubMed 21955276 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 12 6.47 8.36
IC50 2 5.65 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1797652 1 8.36
CHEMBL1938897 1 8.30
CHEMBL1938898 1 8.05
CHEMBL1797648 1 6.97
CHEMBL1795980 1 6.21
CHEMBL378900 1 6.00
CHEMBL1797641 1 5.89
CHEMBL1215658 1 5.51
CHEMBL255520 1 5.43
CHEMBL226102 1 5.30
CHEMBL1797639 1 5.24
CHEMBL1089 PHENELZINE 4.0 1 4.75
CHEMBL1179 1 -
CHEMBL1938899 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1797652 Ki = 4.35 nM 8.36
CHEMBL1938897 Ki = 5.0 nM 8.30
CHEMBL1938898 Ki = 9.0 nM 8.05
CHEMBL1797648 Ki = 107.0 nM 6.97
CHEMBL1795980 Ki = 610.0 nM 6.21
CHEMBL378900 IC50 = 1000.0 nM 6.00
CHEMBL1797641 Ki = 1300.0 nM 5.89
CHEMBL1215658 Ki = 3100.0 nM 5.51
CHEMBL255520 Ki = 3700.0 nM 5.43
CHEMBL226102 IC50 = 5000.0 nM 5.30
CHEMBL1797639 Ki = 5700.0 nM 5.24
CHEMBL1089 PHENELZINE Ki = 18000.0 nM 4.75
CHEMBL1179 Ki = 243000.0 nM -
CHEMBL1938899 Ki = 188000.0 nM -