Assay Detail
Binding
CHEMBL1942829
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Displacement of [125]-hNPW23 from human NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neuropeptides B/W receptor type 1 (CHEMBL1293293) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The discovery of potent antagonists of NPBWR1 (GPR7).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.65 | 8.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1940537 | — | — | 1 | 8.38 |
| CHEMBL1940539 | — | — | 1 | 8.23 |
| CHEMBL1940543 | — | — | 1 | 8.22 |
| CHEMBL1940542 | — | — | 1 | 7.75 |
| CHEMBL1940536 | — | — | 1 | 7.68 |
| CHEMBL1940538 | — | — | 1 | 7.46 |
| CHEMBL1940541 | — | — | 1 | 7.02 |
| CHEMBL1940354 | — | — | 1 | 6.49 |
| CHEMBL1940545 | — | — | 1 | - |
| CHEMBL1938418 | — | — | 1 | - |
| CHEMBL1940544 | — | — | 1 | - |
| CHEMBL1940540 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1940537 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL1940539 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL1940543 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1940542 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1940536 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1940538 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL1940541 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL1940354 | — | IC50 | = | 324.0 | nM | 6.49 |
| CHEMBL1940545 | — | IC50 | - | — | - | |
| CHEMBL1938418 | — | IC50 | - | — | - | |
| CHEMBL1940544 | — | IC50 | - | — | - | |
| CHEMBL1940540 | — | IC50 | - | — | - |