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Assay Detail

CHEMBL1942922

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human CRL2351 cells after 5 days by SRB assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 1 — Organism
Curated By Autocuration

Publication

In vitro inhibition of translation initiation by N,N'-diarylureas--potential anti-cancer agents.
Denoyelle S, Chen T, Chen L, Wang Y, Klosi E, Halperin JA, Aktas BH, Chorev M.
Bioorg Med Chem Lett (2012) 22 : 402 -409
PubMed 22153346 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 5.63 6.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1940102 1 6.16
CHEMBL1940101 1 6.10
CHEMBL1940088 1 6.10
CHEMBL1940100 1 5.85
CHEMBL534675 1 5.75
CHEMBL3216547 1 5.75
CHEMBL1940090 1 5.75
CHEMBL1940089 1 5.64
CHEMBL1940096 1 5.64
CHEMBL1940094 1 5.62
CHEMBL530543 1 5.62
CHEMBL10835 1 5.62
CHEMBL1940093 1 5.62
CHEMBL1940092 1 5.62
CHEMBL1940095 1 5.58
CHEMBL1940087 1 5.55
CHEMBL1940091 1 5.39
CHEMBL3217205 1 5.38
CHEMBL3217204 1 5.30
CHEMBL1940085 1 5.12
CHEMBL1940086 1 5.02

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1940102 IC50 = 700.0 nM 6.16
CHEMBL1940101 IC50 = 800.0 nM 6.10
CHEMBL1940088 IC50 = 800.0 nM 6.10
CHEMBL1940100 IC50 = 1400.0 nM 5.85
CHEMBL534675 IC50 = 1800.0 nM 5.75
CHEMBL3216547 IC50 = 1800.0 nM 5.75
CHEMBL1940090 IC50 = 1800.0 nM 5.75
CHEMBL1940089 IC50 = 2300.0 nM 5.64
CHEMBL1940096 IC50 = 2300.0 nM 5.64
CHEMBL1940094 IC50 = 2400.0 nM 5.62
CHEMBL530543 IC50 = 2400.0 nM 5.62
CHEMBL10835 IC50 = 2400.0 nM 5.62
CHEMBL1940093 IC50 = 2400.0 nM 5.62
CHEMBL1940092 IC50 = 2400.0 nM 5.62
CHEMBL1940095 IC50 = 2600.0 nM 5.58
CHEMBL1940087 IC50 = 2800.0 nM 5.55
CHEMBL1940091 IC50 = 4100.0 nM 5.39
CHEMBL3217205 IC50 = 4200.0 nM 5.38
CHEMBL3217204 IC50 = 5000.0 nM 5.30
CHEMBL1940085 IC50 = 7500.0 nM 5.12
CHEMBL1940086 IC50 = 9500.0 nM 5.02