Assay Detail
Binding
CHEMBL1942933
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Inhibition of FLT3 phosphorylation by cell based assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein kinase FLT3 (CHEMBL1974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 8.11 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1940109 | — | — | 1 | 8.70 |
| CHEMBL1940108 | — | — | 1 | 8.70 |
| CHEMBL1940107 | — | — | 1 | 8.52 |
| CHEMBL1940110 | — | — | 1 | 8.52 |
| CHEMBL1940103 | — | — | 1 | 8.40 |
| CHEMBL1940105 | — | — | 1 | 8.40 |
| CHEMBL1940116 | — | — | 1 | 8.40 |
| CHEMBL1940273 | — | — | 1 | 8.40 |
| CHEMBL1940268 | — | — | 1 | 8.30 |
| CHEMBL1940113 | — | — | 1 | 8.30 |
| CHEMBL1940112 | — | — | 1 | 8.30 |
| CHEMBL1940274 | — | — | 1 | 8.15 |
| CHEMBL1940259 | — | — | 1 | 8.15 |
| CHEMBL1940262 | — | — | 1 | 8.10 |
| CHEMBL1940118 | — | — | 1 | 8.05 |
| CHEMBL1940272 | — | — | 1 | 8.00 |
| CHEMBL1940266 | — | — | 1 | 8.00 |
| CHEMBL1940106 | — | — | 1 | 8.00 |
| CHEMBL1940111 | — | — | 1 | 8.00 |
| CHEMBL1940275 | — | — | 1 | 7.70 |
| CHEMBL1940269 | — | — | 1 | 7.70 |
| CHEMBL1940267 | — | — | 1 | 7.70 |
| CHEMBL1940115 | — | — | 1 | 7.70 |
| CHEMBL1940114 | — | — | 1 | 7.40 |
| CHEMBL1940271 | — | — | 1 | 7.10 |
| CHEMBL1940265 | — | — | 1 | - |
| CHEMBL1940264 | — | — | 1 | - |
| CHEMBL1940263 | — | — | 1 | - |
| CHEMBL1940261 | — | — | 1 | - |
| CHEMBL1940260 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1940109 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1940108 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1940107 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1940110 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1940103 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1940105 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1940116 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1940273 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1940268 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1940112 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1940113 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1940274 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1940259 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1940262 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1940118 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1940266 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1940111 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1940106 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1940272 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1940275 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1940269 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1940267 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1940115 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1940114 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1940271 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1940265 | — | IC50 | > | 400.0 | nM | - |
| CHEMBL1940264 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1940263 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1940261 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1940260 | — | IC50 | > | 60.0 | nM | - |
| CHEMBL1940270 | — | IC50 | > | 800.0 | nM | - |
| CHEMBL1940117 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1940104 | — | IC50 | > | 20.0 | nM | - |