Compound Detail
CHEMBL1940275
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Basic Information
| ChEMBL ID | CHEMBL1940275 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FQGHYVHLTQUXGX-UHFFFAOYSA-N |
4
Targets
6
Activities
1
Assay Types
0
PK Parameters
12
Publications
0
Known Names
Molecular Properties
446.5
MW (Da)
4.35
ALogP
8
HBA
2
HBD
103.2
PSA (Ų)
0.41
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 7.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Platelet-derived growth factor receptor beta CHEMBL1913 | IC50 | 7.7 | 7.7 | 20.0 | 2 |
| Receptor-type tyrosine-protein kinase FLT3 CHEMBL1974 | IC50 | 7.7 | 7.7 | 20.0 | 2 |
| Vascular endothelial growth factor receptor 3 CHEMBL1955 | IC50 | 6.31 | 6.31 | 485.0 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 6.31 | 6.31 | 485.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Platelet-derived growth factor receptor beta | IC50 | = | 20.0 | nM | 7.7 | Inhibition of PDGFRbeta phosphorylation by cell based assay | 22153662 |
| Receptor-type tyrosine-protein kinase FLT3 | IC50 | = | 20.0 | nM | 7.7 | Inhibition of FLT3 phosphorylation by cell based assay | 22153662 |
| Platelet-derived growth factor receptor beta | IC50 | = | 20.0 | nM | 7.7 | Inhibition of PDGFRbeta | 22497760 |
| Receptor-type tyrosine-protein kinase FLT3 | IC50 | = | 20.0 | nM | 7.7 | Inhibition of Flt3 | 22497760 |
| Vascular endothelial growth factor receptor 3 | IC50 | = | 485.0 | nM | 6.31 | Inhibition of VEGFR3 phosphorylation by cell based assay | 22153662 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 485.0 | nM | 6.31 | Inhibition of KDR | 22497760 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30204441 | 10.1021/acs.jmedchem.8b00938 | Mast/stem cell growth factor receptor Kit | 3 |
| 22153662 | 10.1016/j.bmcl.2011.11.019 | Platelet-derived growth factor receptor beta | 1 |
| 22153662 | 10.1016/j.bmcl.2011.11.019 | Vascular endothelial growth factor receptor 3 | 1 |
| 22153662 | 10.1016/j.bmcl.2011.11.019 | Macrophage colony-stimulating factor 1 receptor | 1 |
| 22153662 | 10.1016/j.bmcl.2011.11.019 | Receptor-type tyrosine-protein kinase FLT3 | 1 |
| 22153662 | 10.1016/j.bmcl.2011.11.019 | Platelet-derived growth factor receptor alpha | 1 |
| 22497760 | 10.1016/j.bmcl.2012.03.074 | Platelet-derived growth factor receptor beta | 1 |
| 22497760 | 10.1016/j.bmcl.2012.03.074 | Receptor-type tyrosine-protein kinase FLT3 | 1 |
| 22497760 | 10.1016/j.bmcl.2012.03.074 | Vascular endothelial growth factor receptor 2 | 1 |
| 22497760 | 10.1016/j.bmcl.2012.03.074 | Macrophage colony-stimulating factor 1 receptor | 1 |
| 30204441 | 10.1021/acs.jmedchem.8b00938 | BaF3 | 1 |
| 30204441 | 10.1021/acs.jmedchem.8b00938 | Vascular endothelial growth factor receptor 2 | 1 |
Data from ChEMBL 36 via Core Engine