Assay Detail
Binding
CHEMBL1942930
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Inhibition of VEGFR3 phosphorylation by cell based assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 3 (CHEMBL1955) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 7.20 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1940109 | — | — | 1 | 9.70 |
| CHEMBL1940108 | — | — | 1 | 9.40 |
| CHEMBL1940112 | — | — | 1 | 8.15 |
| CHEMBL1940274 | — | — | 1 | 8.10 |
| CHEMBL1940259 | — | — | 1 | 8.10 |
| CHEMBL1940273 | — | — | 1 | 7.92 |
| CHEMBL1940118 | — | — | 1 | 7.66 |
| CHEMBL1940104 | — | — | 1 | 7.60 |
| CHEMBL1940272 | — | — | 1 | 7.54 |
| CHEMBL1940113 | — | — | 1 | 7.52 |
| CHEMBL1940111 | — | — | 1 | 7.51 |
| CHEMBL1940116 | — | — | 1 | 7.46 |
| CHEMBL1940107 | — | — | 1 | 7.41 |
| CHEMBL1940103 | — | — | 1 | 7.29 |
| CHEMBL1940115 | — | — | 1 | 7.24 |
| CHEMBL1940105 | — | — | 1 | 7.00 |
| CHEMBL1940267 | — | — | 1 | 6.89 |
| CHEMBL1940260 | — | — | 1 | 6.76 |
| CHEMBL1940269 | — | — | 1 | 6.76 |
| CHEMBL1940262 | — | — | 1 | 6.75 |
| CHEMBL1940266 | — | — | 1 | 6.68 |
| CHEMBL1940114 | — | — | 1 | 6.55 |
| CHEMBL1940106 | — | — | 1 | 6.34 |
| CHEMBL1940275 | — | — | 1 | 6.31 |
| CHEMBL1940271 | — | — | 1 | 6.18 |
| CHEMBL1940261 | — | — | 1 | 6.00 |
| CHEMBL1940265 | — | — | 1 | 5.51 |
| CHEMBL1940264 | — | — | 1 | 5.21 |
| CHEMBL1940263 | — | — | 1 | - |
| CHEMBL1940270 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1940109 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL1940108 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL1940112 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1940274 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1940259 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1940273 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1940118 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1940104 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1940272 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL1940113 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1940111 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL1940116 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL1940107 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL1940103 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL1940115 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL1940105 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL1940267 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL1940260 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL1940269 | — | IC50 | = | 172.0 | nM | 6.76 |
| CHEMBL1940262 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL1940266 | — | IC50 | = | 209.0 | nM | 6.68 |
| CHEMBL1940114 | — | IC50 | = | 282.0 | nM | 6.55 |
| CHEMBL1940106 | — | IC50 | = | 453.0 | nM | 6.34 |
| CHEMBL1940275 | — | IC50 | = | 485.0 | nM | 6.31 |
| CHEMBL1940271 | — | IC50 | = | 667.0 | nM | 6.18 |
| CHEMBL1940261 | — | IC50 | = | 1009.0 | nM | 6.00 |
| CHEMBL1940265 | — | IC50 | = | 3063.0 | nM | 5.51 |
| CHEMBL1940264 | — | IC50 | = | 6144.0 | nM | 5.21 |
| CHEMBL1940263 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1940270 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1940268 | — | IC50 | < | 5.0 | nM | - |
| CHEMBL1940117 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1940110 | — | IC50 | < | 5.0 | nM | - |