Assay Detail
Binding
CHEMBL2027406
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Inhibition of KDR
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of new quinoline ether inhibitors with high affinity and selectivity for PDGFR tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 6.42 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2023485 | — | — | 1 | 8.52 |
| CHEMBL2023486 | — | — | 1 | 8.40 |
| CHEMBL1940274 | — | — | 1 | 8.10 |
| CHEMBL2023476 | — | — | 1 | 7.70 |
| CHEMBL2023482 | — | — | 1 | 7.70 |
| CHEMBL2023494 | — | — | 1 | 7.64 |
| CHEMBL2023118 | — | — | 1 | 7.17 |
| CHEMBL2023117 | — | — | 1 | 7.09 |
| CHEMBL2023490 | — | — | 1 | 6.74 |
| CHEMBL2023800 | — | — | 1 | 6.61 |
| CHEMBL1940275 | — | — | 1 | 6.31 |
| CHEMBL2023483 | — | — | 1 | 6.29 |
| CHEMBL2023484 | — | — | 1 | 5.89 |
| CHEMBL2023478 | — | — | 1 | 5.79 |
| CHEMBL2023477 | — | — | 1 | 5.72 |
| CHEMBL2023119 | — | — | 1 | 5.68 |
| CHEMBL2023492 | — | — | 1 | 5.61 |
| CHEMBL2023488 | — | — | 1 | 5.40 |
| CHEMBL2023475 | — | — | 1 | 5.39 |
| CHEMBL2023474 | — | — | 1 | 5.37 |
| CHEMBL2023495 | — | — | 1 | 5.33 |
| CHEMBL2023116 | — | — | 1 | 5.32 |
| CHEMBL2023802 | — | — | 1 | 5.32 |
| CHEMBL2023489 | — | — | 1 | 4.96 |
| CHEMBL2023115 | — | — | 1 | - |
| CHEMBL2023479 | — | — | 1 | - |
| CHEMBL2023480 | — | — | 1 | - |
| CHEMBL2023481 | — | — | 1 | - |
| CHEMBL2023487 | — | — | 1 | - |
| CHEMBL2023491 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2023485 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2023486 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1940274 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2023476 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2023482 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2023494 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL2023118 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL2023117 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL2023490 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL2023800 | — | IC50 | = | 245.0 | nM | 6.61 |
| CHEMBL1940275 | — | IC50 | = | 485.0 | nM | 6.31 |
| CHEMBL2023483 | — | IC50 | = | 515.0 | nM | 6.29 |
| CHEMBL2023484 | — | IC50 | = | 1277.0 | nM | 5.89 |
| CHEMBL2023478 | — | IC50 | = | 1624.0 | nM | 5.79 |
| CHEMBL2023477 | — | IC50 | = | 1919.0 | nM | 5.72 |
| CHEMBL2023119 | — | IC50 | = | 2073.0 | nM | 5.68 |
| CHEMBL2023492 | — | IC50 | = | 2481.0 | nM | 5.61 |
| CHEMBL2023488 | — | IC50 | = | 3954.0 | nM | 5.40 |
| CHEMBL2023475 | — | IC50 | = | 4066.0 | nM | 5.39 |
| CHEMBL2023474 | — | IC50 | = | 4282.0 | nM | 5.37 |
| CHEMBL2023495 | — | IC50 | = | 4718.0 | nM | 5.33 |
| CHEMBL2023116 | — | IC50 | = | 4773.0 | nM | 5.32 |
| CHEMBL2023802 | — | IC50 | = | 4819.0 | nM | 5.32 |
| CHEMBL2023489 | — | IC50 | = | 10990.0 | nM | 4.96 |
| CHEMBL2023115 | — | IC50 | > | 690.0 | nM | - |
| CHEMBL2023479 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2023480 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2023481 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2023487 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2023491 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2023496 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2023801 | — | IC50 | > | 8690.0 | nM | - |
| CHEMBL2023493 | — | IC50 | > | 9740.0 | nM | - |